Ethyl 6-bromopyridazine-4-carboxylate | 1823907-96-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: Ethyl 6-bromopyridazine-4-carboxylate
• CAS: 1823907-96-5
• 化学式: C₇H₇BrN₂O₂
• 分子量: 231.05
• InChiKey: OHIWJDVULBNGHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  52.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] DIAZABICYCLONONENE AND TETRAHYDROPYRIDINE DERIVATIVES AS RENIN INHIBITORS<br/>[FR] DERIVES DE DIAZABICYCLONONENE ET DE TETRAHYDROPYRIDINE UTILISES COMME INHIBITEURS DE LA RENINE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2004096804A1

  公开（公告）日：2004-11-11

  The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives, tetrahydropyridine derivatives, and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

  本发明涉及新型的3,9-二氮杂双环[3.3.1]壬烯衍生物、四氢吡啶衍生物及其相关化合物，以及它们作为活性成分用于制备药物组合物的用途。本发明还涉及相关方面，包括制备这些化合物的方法、含有一种或多种这些化合物的药物组合物，尤其是它们作为肾素抑制剂的用途。
• Diazabicyclononene and tetrahydropyriddine derivatives as renin inhibitors
  申请人：Bezencon Olivier

  公开号：US20060217371A1

  公开（公告）日：2006-09-28

  The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives, tetrahydropyridine derivatives, and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

  本发明涉及新型3,9-二氮杂双环[3.3.1]壬烯衍生物、四氢吡啶衍生物和相关化合物，以及它们作为药物组成物中的活性成分的用途。本发明还涉及相关方面，包括制备该化合物的方法、含有其中一种或多种化合物的药物组成物，尤其是它们作为肾素抑制剂的用途。
• [4-(1,2-EPOXYCYCLOHEXANYL) BUT-3-EN-1-YNYL] AROMATIC AND HETEROAROMATIC ACIDS AND DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY
  申请人：Allergan

  公开号：EP0737190A1

  公开（公告）日：1996-10-16
• EP1622906A1
  申请人：——

  公开号：EP1622906A1

  公开（公告）日：2006-02-08
• US5426118A
  申请人：——

  公开号：US5426118A

  公开（公告）日：1995-06-20