1-(3-phenylpropanoyl)-(3R,4R)-3-[1(R)-(tert-butyldimethylsilyloxy)-ethyl]-4-(acetoxy)-azetidin-2-one | 1197422-22-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 1-(3-phenylpropanoyl)-(3R,4R)-3-[1(R)-(tert-butyldimethylsilyloxy)-ethyl]-4-(acetoxy)-azetidin-2-one
• 英文别名: [(2R,3R)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxo-1-(3-phenylpropanoyl)azetidin-2-yl] acetate
• CAS: 1197422-22-2
• 化学式: C₂₂H₃₃NO₅Si
• 分子量: 419.593
• InChiKey: KENPPPIOPJTHER-MFMILTCTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  72.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(3-phenylpropanoyl)-(3R,4R)-3-[1(R)-(tert-butyldimethylsilyloxy)-ethyl]-4-(acetoxy)-azetidin-2-one 在 盐酸 、 溶剂黄146 作用下， 以 水 、 乙腈 为溶剂， 反应 3.5h， 以93%的产率得到1-(3-phenylpropanoyl)-(3R,4R)-3-[1(R)-hydroxyethyl]-4-(acetoxy)-azetidin-2-one
  参考文献：
  名称：

  β-Lactams Derived from a Carbapenem Chiron Are Selective Inhibitors of Human Fatty Acid Amide Hydrolase versus Human Monoacylglycerol Lipase

  摘要：

  A library of 30 beta-lactams has been prepared from (3R,4R)-3-[(R)-1'-(tbutyldimethylsilyloxy)-ethyl]-4-acetoxy-2-azetidinone, and the corresponding deacetoxy derivative, by sequential N- and O-functionalizations with various omega-alkenoyl and omega-arylalkanoyl chains. All compounds were selective inhibitors of hFAAH versus hMGL, and IC50 values in the nanomolar range (5-14 nM) were recorded for the best representatives. From time-dependent preincubation and rapid dilution studies, and from docking analyses in a homology model of the target enzyme, a reversible mechanism of inhibition of hFAAH is proposed.

  DOI：

  10.1021/jm9008532
• 作为产物：
  描述：

  4-乙酰氧基氮杂环丁酮 、 3-苯丙酰氯 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 以89%的产率得到1-(3-phenylpropanoyl)-(3R,4R)-3-[1(R)-(tert-butyldimethylsilyloxy)-ethyl]-4-(acetoxy)-azetidin-2-one
  参考文献：
  名称：

  β-Lactams Derived from a Carbapenem Chiron Are Selective Inhibitors of Human Fatty Acid Amide Hydrolase versus Human Monoacylglycerol Lipase

  摘要：

  A library of 30 beta-lactams has been prepared from (3R,4R)-3-[(R)-1'-(tbutyldimethylsilyloxy)-ethyl]-4-acetoxy-2-azetidinone, and the corresponding deacetoxy derivative, by sequential N- and O-functionalizations with various omega-alkenoyl and omega-arylalkanoyl chains. All compounds were selective inhibitors of hFAAH versus hMGL, and IC50 values in the nanomolar range (5-14 nM) were recorded for the best representatives. From time-dependent preincubation and rapid dilution studies, and from docking analyses in a homology model of the target enzyme, a reversible mechanism of inhibition of hFAAH is proposed.

  DOI：

  10.1021/jm9008532