(E)-N-methoxy-1-naphthalen-1-ylmethanimine | 155337-27-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (E)-N-methoxy-1-naphthalen-1-ylmethanimine
• CAS: 155337-27-2
• 化学式: C₁₂H₁₁NO
• 分子量: 185.225
• InChiKey: MIBZFPKFMJJYII-UKTHLTGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-N-methoxy-1-naphthalen-1-ylmethanimine 在 dipotassium peroxodisulfate 、 silver(I) nitrite 、 聚合甲醛 、 palladium(II) trifluoroacetate 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 水 、 1,2-二氯乙烷 为溶剂， 反应 56.0h， 生成 2-nitro-1-naphthaldehyde
  参考文献：
  名称：

  通过钯催化螯合辅助 CH 硝化从苯甲醛区域特异性合成取代的 2-硝基苯甲醛

  摘要：

  已经开发出一种由取代苯甲醛区域特异性合成取代 2-硝基苯甲醛的方法，该方法涉及三步法，其中钯催化的螯合辅助 C-H 硝化作为关键步骤。在该方法中，O-甲基醛肟作为钯催化的取代苯甲醛肟的邻硝化的可去除导向基团，并且可以在随后将所得2-硝基苯甲醛肟转化为2-硝基苯甲醛时去除。

  DOI：

  10.1002/ejoc.201402451
• 作为产物：
  描述：

  (E)-1-naphthaldehyde oxime 、 alkaline earth salt of/the/ methylsulfuric acid 以80%的产率得到(E)-N-methoxy-1-naphthalen-1-ylmethanimine
  参考文献：
  名称：

  Dinia, M. N.; Hassikou, A.; Lattes, A., Bulletin des Societes Chimiques Belges, 1993, vol. 102, # 9, p. 623 - 624

  摘要：

  DOI：

文献信息

• Palladium-Catalyzed Oxidative Ethoxycarbonylation of Aromatic C−H Bond with Diethyl Azodicarboxylate
  作者：Wing-Yiu Yu、Wing Nga Sit、Kin-Man Lai、Zhongyuan Zhou、Albert S. C. Chan

  DOI：10.1021/ja710555g

  日期：2008.3.1

  (DEAD) together with Oxone or K2S2O8. Substrates such as 2-arylpyridines, pyrrolidinone, acetylindoline, quinoline, and oximes were ethoxycarbonylated with excellent chemo- and regioselectivities. The catalytic reaction is probably initiated by chelation-assisted cyclopalladation of the ortho-C−H bond. Preliminary studies suggested that reactive ethoxyacyl radicals generated from thermal decomposition

  该通讯描述了使用偶氮二羧酸二乙酯 (DEAD) 和 Oxone 或 K2S2O8 的 Pd(OAc)2 催化芳族 CH 键的乙氧基羰基化反应。2-芳基吡啶、吡咯烷酮、乙酰二氢吲哚、喹啉和肟等底物被乙氧基羰基化，具有优异的化学和区域选择性。催化反应可能是由邻位-CH 键的螯合辅助环钯化引发的。初步研究表明，DEAD 热分解产生的反应性乙氧基酰基自由基参与了酯的形成。
• Diastereoselective Addition of Chlorotitanium Enolate of <i>N</i>-Acyl Thiazolidinethione to <i>O</i>-Methyl Oximes:  A Novel, Stereoselective Synthesis of α,β-Disubstituted β-Amino Carbonyl Compounds via Chiral Auxiliary Mediated Azetine Formation
  作者：Narendra B. Ambhaikar、James P. Snyder、Dennis C. Liotta

  DOI：10.1021/ja029871u

  日期：2003.4.1

  thiazolidin-2-thiones to O-methyl aldoximes. The “anti” azetines can be subsequently converted to the corresponding α,β-disubstituted β-amino carbonyl compound with retention of stereochemistry. The formation of azetine and the product of its “hydrolytic” opening has been confirmed by X-ray crystallographic analyses.

  我们发现了氮杂环丁烷基噻唑烷-2-硫酮的新型和高度非对映选择性合成，该合成利用将 N-酰基噻唑烷-2-硫酮的氯钛烯醇化物添加到 O-甲基醛肟中。“抗”氮杂环丁烷随后可以转化为相应的 α,β-二取代 β-氨基羰基化合物，同时保留立体化学。X 射线晶体学分析证实了氮杂环丁烷及其“水解”打开的产物的形成。
• Oxime substituted imidazoquinolines
  申请人：Kshirsagar A. Tushar

  公开号：US20070066639A1

  公开（公告）日：2007-03-22

  Imidazo-containing compounds (e.g., imidazoquinolines, imidazonaphthyridines, and imidazopyridines) with an oxime substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

  本发明涉及含咪唑基的化合物（例如咪唑喹啉，咪唑萘啶和咪唑吡啶），其在1位上具有肟基取代基，包含这些化合物的药物组合物，中间体以及这些化合物作为免疫调节剂的使用方法，用于诱导动物细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。
• GLYCOSYLTRANSFERASE REVERSIBILITY FOR SUGAR NUCLEOTIDE SYNTHESIS AND MICROSCALE SCANNING
  申请人：Thorson Jon S.

  公开号：US20130004979A1

  公开（公告）日：2013-01-03

  The present invention generally relates to materials and methods for exploiting glycosyltransferase reversibility for nucleotide diphosphate (NDP) sugar synthesis. The present invention provides engineered glycosyltransferase enzymes characterized by improved reaction reversibility and expanded sugar donor specificity as compared to corresponding non-mutated glycosyltransferase enzymes. Such reagents provide advantageous routes to NDP sugars for subsequent use in a variety of biomedical applications, including enzymatic and chemo-enzymatic glycorandomization.

  本发明一般涉及利用糖基转移酶可逆性合成核苷酸二磷酸（NDP）糖的材料和方法。本发明提供了改良反应可逆性并扩展糖供体特异性的工程糖基转移酶酶，与相应的非突变糖基转移酶酶相比，具有更好的反应可逆性和扩展的糖供体特异性。这些试剂提供了有利的NDP糖路线，用于随后在各种生物医学应用中使用，包括酶促和化学酶促糖随机化。
• ACYCLIC OXIMYL HEPATITIS C PROTEASE INHIBITORS
  申请人：Sun Ying

  公开号：US20080125444A1

  公开（公告）日：2008-05-29

  The present invention discloses compounds of formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.