(5R,11S)-N5,N5,N11,N11-tetrakis((S)-1-phenylethyl)-4,6,10,12-tetraoxa-5,11-diphosphadibenzo[ef,kl]heptalene-5,11-diamine | 1215714-06-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (5R,11S)-N5,N5,N11,N11-tetrakis((S)-1-phenylethyl)-4,6,10,12-tetraoxa-5,11-diphosphadibenzo[ef,kl]heptalene-5,11-diamine
• CAS: 1215714-06-9
• 化学式: C₄₄H₄₂N₂O₄P₂
• 分子量: 724.776
• InChiKey: IOUUYKLZLCCQKY-VUXXYHFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.1
• 重原子数：
  52.0
• 可旋转键数：
  10.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  59.04
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  2,2’,6,6’-四氢xy-1,1’-亚苯 、 N,N-bis[(1S)-1-phenylethyl]phosphoramidous dichloride 以 甲苯 为溶剂， 反应 12.0h， 生成 (5R,11S)-N5,N5,N11,N11-tetrakis((S)-1-phenylethyl)-4,6,10,12-tetraoxa-5,11-diphosphadibenzo[ef,kl]heptalene-5,11-diamine 、 (5R,11S)-N5,N5,N11,N11-tetrakis((S)-1-phenylethyl)-4,6,10,12-tetraoxa-5,11-diphosphadibenzo[ef,kl]heptalene-5,11-diamine
  参考文献：
  名称：

  From C2- to D2-symmetry: atropos phosphoramidites with a D2-symmetric backbone as highly efficient ligands in Cu-catalyzed conjugate additions

  摘要：

  Atropos phosphoramidites with the D-2-symmetric biphenyl backbone were diastereoselectively prepared with ease from achiral tetrahydroxy biphenyls. This type of ligands is proved to be highly efficient in the Cu-catalyzed conjugate additions of diethylzinc to alpha,beta-unsaturated ketones and nitroalkenes. The unique D-2-symmetric backbone endows the ligands with an excellent chiral environment. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.04.033