tris(2-aminoethyl) thiosemicarbazide | 1352840-12-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: tris(2-aminoethyl) thiosemicarbazide
• CAS: 1352840-12-0
• 化学式: C₉H₂₄N₁₀S₃
• 分子量: 368.555
• InChiKey: SXNXJPNUHPJEDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  22.0
• 可旋转键数：
  9.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  153.48
• 氢给体数：
  9.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  tris(2-aminoethyl) thiosemicarbazide 、 邻香草醛 以 乙醇 为溶剂， 以62%的产率得到
  参考文献：
  名称：

  Synthesis and characterization of multimeric salicylaldimine thiosemicarbazones and their Pd(II) and Pt(II) complexes

  摘要：

  A series of di- and trithiosemicarbazone ligands as well as their Pd(II) and Pt(II) 1,3,5-triaza-7-phosphaadamantane (PTA) complexes have been synthesised using templated reactions between various substituted salicylaldimine thiosemicarbazone ligands and metal precursors of the general formula cis-[M(PTA)(2)Cl-2], where M = Pd or Pt. Characterization of these complexes was achieved using various analytical and spectroscopic techniques: elemental analysis, ESI-MS, FT-IR, and NMR (H-1, C-13{H-1) and P-31{H-1}) spectroscopy. The data revealed tridentate (O-N-S) coordination of the thiosemicarbazone moieties via the imine nitrogen, thiolato sulfur and phenolic oxygen to each metal center. in vitro biological evaluation of selected compounds was conducted against WHCO1 oesophageal cancer cells. Some of the multimeric compounds display some promising biological activity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2011.10.005
• 作为产物：
  描述：

  三(2-氨基乙基)胺 在 一水合肼 、 sodium hydroxide 作用下， 以 水 为溶剂， 反应 6.0h， 生成 tris(2-aminoethyl) thiosemicarbazide
  参考文献：
  名称：

  Synthesis and characterization of multimeric salicylaldimine thiosemicarbazones and their Pd(II) and Pt(II) complexes

  摘要：

  A series of di- and trithiosemicarbazone ligands as well as their Pd(II) and Pt(II) 1,3,5-triaza-7-phosphaadamantane (PTA) complexes have been synthesised using templated reactions between various substituted salicylaldimine thiosemicarbazone ligands and metal precursors of the general formula cis-[M(PTA)(2)Cl-2], where M = Pd or Pt. Characterization of these complexes was achieved using various analytical and spectroscopic techniques: elemental analysis, ESI-MS, FT-IR, and NMR (H-1, C-13{H-1) and P-31{H-1}) spectroscopy. The data revealed tridentate (O-N-S) coordination of the thiosemicarbazone moieties via the imine nitrogen, thiolato sulfur and phenolic oxygen to each metal center. in vitro biological evaluation of selected compounds was conducted against WHCO1 oesophageal cancer cells. Some of the multimeric compounds display some promising biological activity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2011.10.005