AcNH-DWBipGHPraQGGRGGG-CONH2, Bip: biphenylalanine residue, Pra: L-propargylglycine | 1334782-37-4

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 英文名称: AcNH-DWBipGHPraQGGRGGG-CONH2, Bip: biphenylalanine residue, Pra: L-propargylglycine
• CAS: 1334782-37-4
• 化学式: C₆₆H₈₃N₂₁O₁₇
• 分子量: 1442.52
• InChiKey: IZLBTHDAJBMCNR-OLLPCQKTSA-N

反应信息

• 作为反应物：
  描述：

  5-(3-(2-(2-(2-azidoethoxy)ethoxy)ethyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid 、 AcNH-DWBipGHPraQGGRGGG-CONH2, Bip: biphenylalanine residue, Pra: L-propargylglycine 在 copper(II) sulfate 、 维生素 C 作用下， 以 甲醇 、 二甲基亚砜 、 N,N-二甲基甲酰胺 、 叔丁醇 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  Cofactor-Free Detection of Phosphatidylserine with Cyclic Peptides Mimicking Lactadherin

  摘要：

  Cyclic peptides (cLacs) are designed to mimic the natural phosphatidylserine (PS) binding protein lactadherin. Unlike annexin V or its small molecule mimics, the cLac peptides selectively target PS-presenting membranes with no need for metal cofactors. We further show that a fluorophore-labeled cLac effectively stains early apoptotic cells. The small size and facile conjugation with a variety of imaging tracers make the cLac design promising for imaging cell death in vitro as well as in living organisms.

  DOI：

  10.1021/ja205911n