磷酸二甲酚酯 | 3862-12-2

• 物质功能分类: 有机原料 - 无机酸酯
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 中文名称: 磷酸二甲酚酯
• 中文别名: 三(二甲苯基)磷酸酯；三(2,4-二甲苯基)磷酸酯；磷酸三(二甲苯)酯；TXP；阻燃剂TXP；磷酸二甲酚(1:3)酯
• 英文名称: phosphoric acid tris-(2,4-dimethyl-phenyl ester)
• 英文别名: Phosphorsaeure-tris-(2,4-dimethyl-phenylester)；2,4-dimethyl-phenol, phosphate (3:1)；tris(2,4-dimethylphenyl) phosphate；trixylenyl phosphate；trixylyl phosphate；Tris-(2,4-dimethyl-phenyl)-phosphat
• CAS: 3862-12-2；25155-23-1
• 化学式: C₂₄H₂₇O₄P
• 分子量: 410.45
• InChiKey: KOWVWXQNQNCRRS-UHFFFAOYSA-N

物化性质

• 熔点：
  -19.9°C
• 沸点：
  ≥300 °C(lit.)
• 密度：
  1.136 g/mL at 20 °C(lit.)
• 闪点：
  232℃
• 溶解度：
  可溶于乙腈（少许）、氯仿（少许）
• LogP：
  6.38 at 25℃
• 物理描述：
  Toxic by ingestion and skin absorption when pure. Produces phosphorus oxide gases during combustion. Primary hazard is threat to the environment. Immediate steps should be taken to limit spread to the environment. Easily penetrates soil to contaminate groundwater and nearby waterways.
• 颜色/状态：
  Glassy
• 自燃温度：
  650 °F (USCG, 1999)
• 折光率：
  Index of refraction: 1.5550 @ 20 °C

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

ADMET

毒理性

• 解毒与急救

基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，并在需要时辅助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，并在必要时进行治疗……。监测休克，并在必要时进行治疗……。预期癫痫发作，并在必要时进行治疗……。对于眼睛污染，立即用水冲洗眼睛。在转运过程中，用生理盐水连续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的干呕反射且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……。在去污后，用干燥的无菌敷料覆盖皮肤烧伤……。/毒药A和B/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

高级治疗：对于昏迷、严重肺水肿或呼吸停止的患者，考虑进行口咽或鼻咽插管以控制气道。使用带有气囊面罩的装置进行正压通气技术可能有益。监测心率和必要时治疗心律失常。 ... 开始静脉输液，使用5%葡萄糖盐水/生理盐水： "保持开放"，最低流速/。如果出现低血容量的迹象，使用乳酸钠林格氏液。注意液体过载的迹象。考虑使用药物治疗肺水肿。对于伴有低血容量迹象的低血压，谨慎给予液体。注意液体过载的迹象。使用地西泮（安定）治疗癫痫。使用丙美卡因氢氯化物协助眼部冲洗。 /毒药A和B/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  9
• 海关编码：
  2919900090

制备方法与用途

化学性质：无色的油状液体，略有气味，微溶于水，并能溶解于大多数有机溶剂。

反应信息

• 作为反应物：
  描述：

  磷酸二甲酚酯 、 氰化钾 生成 2,4-二甲基苯甲腈
  参考文献：
  名称：

  Kreysler, Chemische Berichte, 1885, vol. 18, p. 1716

  摘要：

  DOI：
• 作为产物：
  描述：

  2,4-二甲基苯酚 在 三氯氧磷 作用下， 生成 磷酸二甲酚酯
  参考文献：
  名称：

  Kreysler, Chemische Berichte, 1885, vol. 18, p. 1716

  摘要：

  DOI：

文献信息

• [EN] NOVEL TETRAOXASPIRO[5.5]UNDECANE BASED PHOSPHATE COMPOUNDS AND THEIR USE AS FLAME RETARDANTS<br/>[FR] NOUVEAUX COMPOSÉS DE PHOSPHATE À BASE DE TÉTRAOXASPIRO[5.5]UNDÉCANE ET LEUR UTILISATION COMME IGNIFUGEANTS
  申请人：PERSTORP AB

  公开号：WO2013058690A1

  公开（公告）日：2013-04-25

  The present invention refers to a novel phosphate compound of Formula (I), wherein n is an integer and at least 1, p and q individually is 0 or an integer between 1 and 10, substituents R1 and R2 individually is (i) a linear or branched C1-C6 divalent alkyl group optionally substituted by an aromatic ring, or (ii) a group of formula -R3-0- wherein R3 is a C1-C6 divalent alkyl group, and wherein Ar is an aromatic ring, optionally substituted by at least one linear or branched C1-C6 alkyl group. The present invention in further aspects refers to a process for the production of said novel phosphate and to the use of said novel phosphate as flame retardant.

  本发明涉及一种新型磷酸盐化合物，其化学式为（I），其中n是一个整数且至少为1，p和q分别为0或介于1和10之间的整数，取代基R1和R2分别是（i）线性或支链的C1-C6二价烷基基团，可选择地被芳香环取代，或（ii）具有化学式-R3-O-的基团，其中R3是C1-C6二价烷基基团，Ar是一个芳香环，可选择地被至少一个线性或支链的C1-C6烷基基团取代。本发明还涉及一种用于制备所述新型磷酸盐的方法，并将所述新型磷酸盐用作阻燃剂。
• Selective Hydrogenation Catalyst and Methods of Making and Using Same
  申请人：Cheung Tin-Tack Peter

  公开号：US20100228065A1

  公开（公告）日：2010-09-09

  A composition comprising a supported hydrogenation catalyst comprising palladium and an organophosphorous compound, the supported hydrogenation catalyst being capable of selectively hydrogenating highly unsaturated hydrocarbons to unsaturated hydrocarbons. A method of making a selective hydrogenation catalyst comprising contacting a support with a palladium-containing compound to form a palladium supported composition, contacting the palladium supported composition with an organophosphorus compound to form a catalyst precursor, and reducing the catalyst precursor to form the catalyst. A method of selectively hydrogenating highly unsaturated hydrocarbons to an unsaturated hydrocarbon enriched composition comprising contacting a supported catalyst comprising palladium and an organophosphorous compound with a feed comprising highly unsaturated hydrocarbon under conditions suitable for hydrogenating at least a portion of the highly unsaturated hydrocarbon feed to form the unsaturated hydrocarbon enriched composition.

  一种包括支持的氢化催化剂的组合物，其中氢化催化剂包括钯和有机磷化合物，支持的氢化催化剂能够选择性地将高度不饱和烃氢化为不饱和烃。一种制备选择性氢化催化剂的方法，包括将支持物与含钯化合物接触以形成支持的钯组合物，将支持的钯组合物与有机磷化合物接触以形成催化剂前体，并还原催化剂前体以形成催化剂。一种将高度不饱和烃选择性氢化为富含不饱和烃的组合物的方法，包括将包括钯和有机磷化合物的支持催化剂与含高度不饱和烃的进料接触，在适宜的氢化条件下至少部分氢化高度不饱和烃进料以形成富含不饱和烃的组合物。
• High purity monoalkyltin compounds and uses thereof
  申请人：ARKEMA FRANCE

  公开号：EP2123659A1

  公开（公告）日：2009-11-25

  The present invention relates to high purity monoalkyltin compounds, more specifically to alkyltin compound compositions containing monoalkyltin as major compound, and minor quantities of di- and/or trialkyltin compounds. The present invention also relates to the preparation processes of such high purity monoalkyltin compounds, as well as to the uses of said monoalkyltin compounds as chlorine-containing polymer-stabilisers, glass coating chemicals and catalysts, as well as articles comprising at least one polymer matrix and a high purity monoalkyltin compound.

  本发明涉及高纯度的单烷基锡化合物，更具体地是含有单烷基锡作为主要化合物的烷基锡化合物组合物，以及少量的二烷基锡和/或三烷基锡化合物。本发明还涉及制备这种高纯度单烷基锡化合物的过程，以及将所述单烷基锡化合物用作含氯聚合物稳定剂、玻璃涂层化学品和催化剂的用途，以及包含至少一个聚合物基质和高纯度单烷基锡化合物的制品。
• Bismaleamic acid, bismaleimide and cured product thereof
  申请人：Uera Kazuyoshi

  公开号：US20090312519A1

  公开（公告）日：2009-12-17

  A bismaleamic acid obtained by reacting a bifunctional phenylene ether oligomer diamine, obtained by introducing aromatic amino groups into both terminals of a specific bifunctional phenylene ether oligomer, with maleic anhydride, a bismaleimide obtained from the bismaleamic acid as a raw material, which bismaleimide has high heat resistance, low dielectric characteristics and excellent solvent solubility and exhibits only a small change in dielectric characteristics even in high humidity, a curable resin composition containing the above bismaleimide and a cured product obtained by curing the curable resin composition.

  通过将具有芳香族氨基团的双官能苯醚寡聚二胺与马来酸酐反应获得的双马来酰胺酸，再以该双马来酰胺酸为原料制备的双马来酰亚胺，该双马来酰亚胺具有高耐热性、低介电特性和优异的溶剂溶解性，即使在高湿度条件下也仅表现出微小的介电特性变化，以及包含上述双马来亚胺的可固化树脂组合物和通过固化可固化树脂组合物获得的固化产物。
• NOVEL PHOSPHORUS COMPOUNDS, SYNTHESIS METHOD THEREOF, AND POLYCARBONATE RESIN COMPOSITION INCLUDING THEM
  申请人：RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY

  公开号：US20190071566A1

  公开（公告）日：2019-03-07

  The present disclosure relates to a phosphorus compound represented by the following Chemical Formula 1. In the above Chemical Formula 1, Ar is aryl and R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are each independently H, substitutable linear or branched C 1 -C 20 alkyl and substitutable C 6 -C 20 aryl, the aryl includes a member selected from the group consisting of phenyl, biphenyl, naphthalene, fluorene, anthracene, phenanthrene, pyrene, fluoranthen, chrysene, benzofluoranthen, perylene, quinoline, indenoanthracene, indenophenanthrene, hydroanthracene, dibenzothiophen, dibenzofuran, and combinations thereof, and the substitution is substitution with C 1 -C 6 alkyl or C 6 -C 20 aryl, but may not be limited thereto.

  本公开涉及由下述化学式1所表示的磷化合物。在上述化学式1中，Ar为芳基，R1、R2、R3、R4、R5和R6各自独立地为H、可替代的线性或支链状C1-C20烷基和可替代的C6-C20芳基，其中芳基包括从苯基、联苯基、萘、芴、蒽、菲、芘、氟蒽、芘、苊、苯并氟蒽、苝、喹啉、茚并蒽、茚并菲、羟基蒽、二苯并噻吩、二苯并呋喃和其组合中选择的成员，取代是取代为C1-C6烷基或C6-C20芳基，但不限于此。