2-甲基吡啶,3-仲-丁基-(6CI) | 117342-56-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-甲基吡啶,3-仲-丁基-(6CI)
• 中文别名: 3-仲-丁基-2-甲基吡啶
• 英文名称: 3-sec-butyl-2-methyl-pyridine
• 英文别名: 3-sec-Butyl-2-methyl-pyridin；2-Picoline, 3-sec-butyl-；3-butan-2-yl-2-methylpyridine
• CAS: 117342-56-0
• 化学式: C₁₀H₁₅N
• 分子量: 149.236
• InChiKey: PBZXAOLPZNLHMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 、 palladium on activated charcoal 、 potassium acetate 作用下， 生成 2-甲基吡啶,3-仲-丁基-(6CI)
  参考文献：
  名称：

  Ishiguro et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1958, vol. 78, p. 220,223

  摘要：

  DOI：

文献信息

• HETEROCYCLIC DERIVATIVES AS OREXIN ANTAGONISTS
  申请人：Gobbi Luca

  公开号：US20080249125A1

  公开（公告）日：2008-10-09

  The present invention relates to compounds of formula wherein R 1 , R 2 , R 3 , and R 4 are as defined herein and hetaryl is a one or two ring-membered heteroaromatic ring system, connected to the carbon atoms of the piperidine group selected from the group consisting of or to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. These compounds are orexin receptor antagonists and may be useful in the treatment of disorders in which orexin pathways are involved, like sleep disorders.

  本发明涉及以下式中的化合物，其中R1、R2、R3和R4如本文所定义，而hetaryl是一个或两个环成员的杂芳环系统，连接到从以下群中选择的哌啶基的碳原子，或者是药用适宜的酸盐、光学纯对映体、拉克酸盐或二对映异构体混合物。这些化合物是促进睡眠受体拮抗剂，可能在涉及促进睡眠途径的疾病治疗中有用，如睡眠障碍。
• Thiazole Derivatives as Protein Kinase Inhibitors
  申请人：Reddy Panduranga Adulla P.

  公开号：US20100331313A1

  公开（公告）日：2010-12-30

  The present invention relates to novel Thiazole Derivatives, compositions comprising the Thiazole Derivatives, and methods for using the Thiazole Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase.
• BICYCLIC PIPERIDINE AND PIPERAZINE DERIVATIVES AS GPCR MODULATORS FOR THE TREATMENT OF OBESITY, DIABETES AND OTHER METABOLIC DISORDERS
  申请人：Boyle Craig D.

  公开号：US20120021976A1

  公开（公告）日：2012-01-26

  The present invention relates to Bicyclic Piperidine and piperazine Derivatives, compositions comprising a Bicyclic Piperidine and piperazine Derivative, and methods of using the Bicyclic Piperidine and piperazine Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a GPCR in a patient.
• US8067598B2
  申请人：——

  公开号：US8067598B2

  公开（公告）日：2011-11-29