4-methyl-2-phenyl-N-((1S)-2,2,2-trifluoro-1-{4-[(hydroxyamino)carbonyl]phenyl}ethyl)-4H-furo[3,2-b]pyrrole-5-carboxamide | 1332891-59-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 4-methyl-2-phenyl-N-((1S)-2,2,2-trifluoro-1-{4-[(hydroxyamino)carbonyl]phenyl}ethyl)-4H-furo[3,2-b]pyrrole-5-carboxamide
• 英文别名: 4-methyl-2-phenyl-N-[(1S)-2,2,2-trifluoro-1-[4-(hydroxycarbamoyl)phenyl]ethyl]furo[3,2-b]pyrrole-5-carboxamide
• CAS: 1332891-59-4
• 化学式: C₂₃H₁₈F₃N₃O₄
• 分子量: 457.409
• InChiKey: PNCSWUPNBUCVLN-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  96.5
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF
  申请人：Blackburn Christopher

  公开号：US20110212969A1

  公开（公告）日：2011-09-01

  This invention provides compounds of formula (I): wherein ring A, X 1 , X 2 , X 3 , R 2 , R 4b , R 10 , and G have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.

  这项发明提供了式（I）的化合物： 其中环A、X1、X2、X3、R2、R4b、R10和G的取值如规范中所述，可用作HDAC6的抑制剂。该发明还提供了包括该发明化合物的药物组合物，以及在治疗增殖性、炎症性、感染性、神经系统或心血管疾病或紊乱中使用该组合物的方法。
• US20140275093A1
  申请人：——

  公开号：US20140275093A1

  公开（公告）日：2014-09-18
• US9382197B2
  申请人：——

  公开号：US9382197B2

  公开（公告）日：2016-07-05
• [EN] SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF<br/>[FR] ACIDES HYDROXAMIQUES SUBSTITUÉS ET LEURS UTILISATIONS
  申请人：MILLENNIUM PHARM INC

  公开号：WO2011106632A1

  公开（公告）日：2011-09-01

  This invention provides compounds of formula (I) wherein ring A, X1, X2, X3, R2, R4b, R10, and G have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.