6-(二甲氧基甲基)-2-疏基嘧啶-4-醇 | 90370-38-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 6-(二甲氧基甲基)-2-疏基嘧啶-4-醇
• 英文名称: 4-Dimethoxymethyl-6-hydroxy-2-thiopyrimidin
• 英文别名: 6-dimethoxymethyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one；6-(Dimethoxymethyl)-2-mercaptopyrimidin-4-OL；6-(dimethoxymethyl)-2-sulfanylidene-1H-pyrimidin-4-one
• CAS: 90370-38-0
• 化学式: C₇H₁₀N₂O₃S
• 分子量: 202.234
• InChiKey: VNDSDTFFQWATLN-UHFFFAOYSA-N

物化性质

• 密度：
  1.34±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  60.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• TELOMERASE INHIBITORS AND METHODS OF THEIR USE
  申请人：Geron Corporation

  公开号：EP1109796A1

  公开（公告）日：2001-06-27
• US6518268B1
  申请人：——

  公开号：US6518268B1

  公开（公告）日：2003-02-11
• [EN] TELOMERASE INHIBITORS AND METHODS OF THEIR USE<br/>[FR] INHIBITEURS DE TELOMERASE ET LEURS PROCEDES D'UTILISATION
  申请人：GERON CORP

  公开号：WO2001002377A1

  公开（公告）日：2001-01-11

  Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatmnet of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.