2-pyridyltriphenylphosphonium hexafluorophosphate | 1108748-87-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-pyridyltriphenylphosphonium hexafluorophosphate
• CAS: 1108748-87-3
• 化学式: C₂₃H₁₉NP*F₆P
• 分子量: 485.348
• InChiKey: MLRAXTDCEYRQKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.08
• 重原子数：
  32.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.89
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  2-氟吡啶 、 三苯基膦 在 sodium hexaflorophosphate 作用下， 反应 2.0h， 以78%的产率得到2-pyridyltriphenylphosphonium hexafluorophosphate
  参考文献：
  名称：

  Synthesis of Phosphonium Salts—Phosphine Structure and Inorganic Salts Effects

  摘要：

  Solvent-free reactions of 2- and 3-halopyridines with PPh3, PBu3, and PCy3 were studied under conventional heating, as well as under microwave irradiation. No difference was observed in the reaction course between classical and microwave reactions. 2-Bromopyridine gave quantitative yields of 2-pyridyltriphenylphosphonium bromide within few minutes at 190 degrees C. Equimolar amounts of some inorganic salts (LiPF6, LiOTf, LiBr NaPF6, KPF6) were necessary for the reactions of the other 2-halopyridines. 3-Halopyridines did not react with PPh3 even in the presence of LiPF6. Their reactions with PCy3 in the presence of LiPF6 resulted in the quantitative formation of dicyclohexylphosphine oxide.

  DOI：

  10.1080/10426500701545950