4-(1,1-Dimethyl-pentyl)-1,2-dimethoxy-benzene | 117053-69-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(1,1-Dimethyl-pentyl)-1,2-dimethoxy-benzene
• 英文别名: 1,2-Dimethoxy-4-(2-methylhexan-2-yl)benzene
• CAS: 117053-69-7
• 化学式: C₁₅H₂₄O₂
• 分子量: 236.354
• InChiKey: XHKDFKYXQTWLNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-甲基-2-己醇 、 邻苯二酚 、 硫酸二甲酯 以60%的产率得到
  参考文献：
  名称：

  BEGER, J.;MEERBOTE, M., J. PRAKT. CHEM., 330,(1988) N 1, 119-125

  摘要：

  DOI：

文献信息

• 6-aryl-7-substituted-3-(1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as inhibitors of the STAT3 pathway with anti-proliferative activity
  申请人：UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

  公开号：US11111253B2

  公开（公告）日：2021-09-07

  Compounds that selectivity inhibit the STAT3 pathway and not the STAT1 pathway and exhibit anti-proliferative activity are disclosed. Also disclosed are methods of treatment of cancers that are characterized by overexpression of STAT3, which are safer that other therapies.

  本研究公开了选择性抑制 STAT3 通路而非 STAT1 通路并具有抗增殖活性的化合物。还公开了治疗以 STAT3 过表达为特征的癌症的方法，这些方法比其他疗法更安全。
• Beger, J.; Meerbote, M., Journal fur praktische Chemie (Leipzig 1954), 1988, vol. 330, # 1, p. 119 - 125
  作者：Beger, J.、Meerbote, M.

  DOI：——

  日期：——
• 6-aryl-7-substituted-3-(1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as Inhibitors of the STAT3 Pathway with Anti-Proliferative Activity
  申请人：University of Pittsburgh - Of the Commonwealth System of Higher Education

  公开号：US20200339602A1

  公开（公告）日：2020-10-29

  Compounds that selectivity inhibit the STAT3 pathway and not the STAT1 pathway and exhibit anti-proliferative activity are disclosed. Also disclosed are methods of treatment of cancers that are characterized by overexpression of STAT3, which are safer that other therapies.