2-acetoxy-5-ethoxy-benzaldehyde | 138116-08-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 2-acetoxy-5-ethoxy-benzaldehyde
• 英文别名: 2-Acetoxy-5-aethoxy-benzaldehyd；4-Ethoxy-2-formylphenyl acetate；(4-ethoxy-2-formylphenyl) acetate
• CAS: 138116-08-2
• 化学式: C₁₁H₁₂O₄
• 分子量: 208.214
• InChiKey: BCVGMKBXKLJOFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  乙基(二苯基磷酰)乙酸酯 、 2-acetoxy-5-ethoxy-benzaldehyde 在 盐酸 、 sodium hydroxide 作用下， 生成 3-diphenylphosphoryl-6-ethoxychromen-2-one
  参考文献：
  名称：

  Phosphonates and phosphine oxides as reagents in a one-pot synthesis of coumarins

  摘要：

  Diethyl coumarin-3-phosphonates and Diphenyl coumarin-3-phosphinyloxide are obtained in mild conditions in one step, from acetoxysalicylaldehydes and triethyl phosphonoacetate or diphenyl phosphinyloxide acetate, by the use of a liquid/liquid phase transfer process without catalysor.

  DOI：

  10.1016/s0040-4039(00)92380-3
• 作为产物：
  描述：

  乙酸酐 、 alkaline earth salt of/the/ methylsulfuric acid 生成 2-acetoxy-5-ethoxy-benzaldehyde
  参考文献：
  名称：

  Hantzsch, Journal fur praktische Chemie (Leipzig 1954), 1880, vol. <2>22, p. 461

  摘要：

  DOI：

文献信息

• [EN] PROCESS FOR THE PREPARATION OF 1,4-DIHYDROPYRIDINES AND NOVEL 1,4-DIHYDROPYRIDINES USEFUL AS THERAPEUTIC AGENTS<br/>[FR] PROCEDE DE PREPARATION DE 1,4-DIHYDROPYRIDINES ET NOUVELLES 1,4-DIHYDROPYRIDINES UTILES EN TANT QU'AGENTS THERAPEUTIQUES
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2003099790A1

  公开（公告）日：2003-12-04

  The present invention provides a process for the preparation of 1,4-dihydropyridines of the formula (1), wherein R1 is H, NO2, Cl, OAc, OH, R2 is H, NO2, Cl, -O-CH2-O-, OMe, OAc, OEt, OH, R3 is H, NO2, Cl, N(Me)2, -O- CH2 -O-, OMe, OAc, OH, R4 is H, OMe, OAc, OH, R5 is H, Cl, I, and R6 and R7 are either methyl, ethyl or both by preparing a mixture of an aromatic aldehyde, alkyl acetoacetate and a source of ammonia, adsorbing the prepared mixture and adsorbent till adsorbent becomes free flowing, heating the material so obtained under microwave irradiation, cooling the reaction mixture and recovering the compound of formula (1). The present invention also relates to novel 1,4-dihydropyridines with cardiovascular activity.

  本发明提供了一种制备1,4-二氢吡啶的方法，其化学式为（1），其中R1为H、NO2、Cl、OAc、OH，R2为H、NO2、Cl、-O-CH2-O-、OMe、OAc、OEt、OH，R3为H、NO2、Cl、N(Me)2、-O- CH2 -O-、OMe、OAc、OH，R4为H、OMe、OAc、OH，R5为H、Cl、I，R6和R7为甲基、乙基或两者的混合物，通过制备芳香醛、醋酸烯酮酯和氨源的混合物，吸附制备的混合物和吸附剂直至吸附剂变得自由流动，加热所得材料在微波辐射下，冷却反应混合物，并回收化合物的方法。该发明还涉及具有心血管活性的新型1,4-二氢吡啶。
• Process for the preparation of 1,4 - dihydropyridines and novel 1,4-dihydropyridines useful as therapeutic agents
  申请人：COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

  公开号：US20030230478A1

  公开（公告）日：2003-12-18

  The present invention provides a process for the preparation of 1,4-dihydropyridines of the formula 1 1 wherein R 1 is H, NO 2 , Cl, OAc, OH, R 2 is H, NO 2 , Cl, —O—CH 2 —O—, OMe, OAc, OEt, OH, R 3 is H, NO 2 , Cl, N(Me) 2 , —O—CH 2 —O—, OMe, OAc, OH, R 4 is H, OMe, OAc, OH, R 5 is H, Cl, I, and R 6 and R 7 are either methyl, ethyl or both by preparing a mixture of an aromatic aldehyde, alkyl acetoacetate and a source of ammonia, adsorbing the prepared mixture on adsorbent till adsorbent becomes free flowing, heating the material so obtained under microwave irradiation, cooling the reaction mixture and recovering the compound of formula I. The present invention also relates to novel 1,4-dihydropyridines.

  本发明提供了一种制备式11中R1为H、NO2、Cl、OAc、OH，R2为H、NO2、Cl、—O—CH2—O—、OMe、OAc、OEt、OH，R3为H、NO2、Cl、N(Me)2、—O—CH2—O—、OMe、OAc、OH，R4为H、OMe、OAc、OH，R5为H、Cl、I，R6和R7为甲基、乙基或两者的1,4-二氢吡啶的制备方法，包括制备芳香醛、醋酸酯和氨源的混合物，将制备好的混合物吸附在吸附剂上直至吸附剂变得自由流动，将所得材料在微波辐射下加热，冷却反应混合物并回收式I的化合物。本发明还涉及新型的1,4-二氢吡啶。
• Phosphonates and phosphine oxides as reagents in a one-pot synthesis of coumarins
  作者：Pascal Bouyssou、Jacques Chenault

  DOI：10.1016/s0040-4039(00)92380-3

  日期：1991.9

  Diethyl coumarin-3-phosphonates and Diphenyl coumarin-3-phosphinyloxide are obtained in mild conditions in one step, from acetoxysalicylaldehydes and triethyl phosphonoacetate or diphenyl phosphinyloxide acetate, by the use of a liquid/liquid phase transfer process without catalysor.
• Hantzsch, Journal fur praktische Chemie (Leipzig 1954), 1880, vol. <2>22, p. 461
  作者：Hantzsch

  DOI：——

  日期：——