O-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine hydrochloride | 858943-31-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: O-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine hydrochloride
• 英文别名: O-[(6-pyrazol-1-ylpyridin-3-yl)methyl]hydroxylamine;hydrochloride
• CAS: 858943-31-4
• 化学式: C₉H₁₀N₄O*ClH
• 分子量: 226.666
• InChiKey: MKOACOUGSOTDFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.08
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  66
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  、 O-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine hydrochloride 在 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  6-11 Bicyclic erythromycin derivatives

  摘要：

  本发明公开了具有以下式I、II、III或IV的化合物，或其拉克米特、对映体、位置异构体、盐、酯或前药： 具有抗菌性能。本发明还涉及包括上述化合物的药物组合物，用于治疗需要抗生素治疗的受试者。该发明还涉及通过给予包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。该发明还包括制备本发明化合物的方法。

  公开号：

  US20050187169A1
• 作为产物：
  描述：

  O-((6-(1H-吡唑-1-基)吡啶-3-基)甲基)羟胺 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 以36.7%的产率得到O-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine hydrochloride
  参考文献：
  名称：

  WO2006/68102

  摘要：

  公开号：

文献信息

• SUBSTITUTED 8 -PYRIDINYL-DIHYDROSPIRO- CYCLOALKYL -PYRIMIDO 1,2-a PYRIMIDIN-6-ONE AND 8 -PYRIMIDIN YL-DIHYDROSPIRO- CYCLOALKYL -PYRIMIDO 1,2-a PYRIMIDIN-6-ONE DERIVATIVES AND THEIR USE AGAINST NEUROGENERATIVE DISEASES
  申请人：Sanofi-Aventis

  公开号：EP1603915A1

  公开（公告）日：2005-12-14
• US7414030B2
  申请人：——

  公开号：US7414030B2

  公开（公告）日：2008-08-19
• [EN] SUBSTITUTED 8'-PYRIDINYL-DIHYDROSPIRO-[CYCLOALKYL]-PYRIMIDO [1,2-a] PYRIMIDIN-6-ONE AND 8'-PYRIMIDINYL-DIHYDROSPIRO-[CYCLOALKYL]-PYRIMIDO [1,2-a] PYRIMIDIN-6-ONE DERIVATIVES AND THEIR USE AGAINST NEUROGENERATIVE DISEASES<br/>[FR] DERIVES DE 8'-PYRIDINYL-DIHYDROSPIRO-(CYCLOALKYL)-PYRIMIDO (1,2-A) PYRIMIDIN-6-ONE ET DE 8'-PYRIMIDINYL-DIHYDROSPIRO-(CYCLOALKYL)-PYRIMIDO (1,2-A) PYRIMIDIN-6-ONE SUBSTITUES ET UTILISATION DE CES DERIVES CONTRE LES MALADIES NEURODEGENERATIVES
  申请人：SANOFI SYNTHELABO

  公开号：WO2004078760A1

  公开（公告）日：2004-09-16

  The invention relates to a dihydrospiro-[cycloalkyl]-pyrimidone derivative represented by formula (I) or a salt thereof: wherein: X represents two hydrogen atoms, a sulfur atom, an oxygen atom or a C1-2 alkyl group and a hydrogen atom; Y represents a bond, a carbonyl group, a methylene group optionally substituted; R1 represents a 2, 3 or 4-­pyridine ring or a 2, 4 or 5-pyrimidine ring, the ring being optionally substituted; R2 represents a benzene ring or a naphthalene ring; the rings being optionally substituted; R3 represents a hydrogen atom, a C1-6 alkyl group or a halogen atom; m represents 1 to 4 n represent 0 to 3 p represents 0 to 2 q represents 0 to 2, p+ q being inferior to 4. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β, such as Alzheimer disease.
• [EN] 6-11 BICYCLIC ERYTHROMYCIN DERIVATIVES<br/>[FR] DERIVES D'ERYTHROMYCINE 6-11 BICYCLIQUE
  申请人：ENANTA PHARM INC

  公开号：WO2005067564A2

  公开（公告）日：2005-07-28

  The present invention discloses compounds of formulaes I, II, III, or IV, or a 5 racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.