4-[(6-chloropyridin-3-yl)methyl-cyclopropylamino]-5H-1,3-thiazol-2-one | 1204064-72-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-[(6-chloropyridin-3-yl)methyl-cyclopropylamino]-5H-1,3-thiazol-2-one
• CAS: 1204064-72-1
• 化学式: C₁₂H₁₂ClN₃OS
• 分子量: 281.766
• InChiKey: AMBJTTLOCMHJHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  70.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (6-氯-吡啶-3-甲基)-环丙基-胺 、 4-硫代噻唑烷-2-酮 以 乙醇 为溶剂， 以18%的产率得到4-[(6-chloropyridin-3-yl)methyl-cyclopropylamino]-5H-1,3-thiazol-2-one
  参考文献：
  名称：

  Discovery, synthesis, and evaluation of N-substituted amino-2(5H)-oxazolones as novel insecticides activating nicotinic acetylcholine receptors

  摘要：

  N-Substituted amino-2(5H)-oxazolones A are a novel class of insecticides acting as nicotinic acetylcholine receptor (nAChR) agonists and show potent activity against hemipteran insect species. Here we report the discovery and preparation of this class of chemistry. Our efforts in SAR elucidation, biological activity evaluation, as well as mode-of-action studies are also presented. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.03.037

文献信息

• [EN] INSECTICIDAL CYCLIC CARBONYL AMIDINES<br/>[FR] CARBONYL-AMIDINES CYCLIQUES INSECTICIDES
  申请人：DU PONT

  公开号：WO2010005692A2

  公开（公告）日：2010-01-14

  Disclosed are compounds of Formula (I), including all stereoisomers, and salts thereof, wherein Y is O, S, NR5 or CR3R4, G is a direct bond, and Z is CR3R4 or NR5; or Y is CR3R4, G is a direct bond, and Z is O or S; or Y is O, S, NR5 or CR3R4, G is CR3R4, and Z is O, S, NR5 or CR3R4; or Y is O, and G–Z is CH=CH; or Y–G is CH=CH, and Z is O, S or NR5; and R1, R2, R3, R4, R5 and Q are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.
• Discovery, synthesis, and evaluation of N-substituted amino-2(5H)-oxazolones as novel insecticides activating nicotinic acetylcholine receptors
  作者：Wenming Zhang、James D. Barry、Daniel Cordova、Stephen F. McCann、Eric A. Benner、Kenneth A. Hughes

  DOI：10.1016/j.bmcl.2014.03.037

  日期：2014.5

  N-Substituted amino-2(5H)-oxazolones A are a novel class of insecticides acting as nicotinic acetylcholine receptor (nAChR) agonists and show potent activity against hemipteran insect species. Here we report the discovery and preparation of this class of chemistry. Our efforts in SAR elucidation, biological activity evaluation, as well as mode-of-action studies are also presented. (C) 2014 Elsevier Ltd. All rights reserved.