2-(2-chlorophenyl)-N-(2-methoxy-2'-methyl[3,4'-bipyridine]-6-yl)-3-methyl-imidazolo[1,2-a]pyridin-8-amine | 1239719-36-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(2-chlorophenyl)-N-(2-methoxy-2'-methyl[3,4'-bipyridine]-6-yl)-3-methyl-imidazolo[1,2-a]pyridin-8-amine
• 英文别名: 2-(2-chlorophenyl)-N-(2-methoxy-2'-methyl[3,4'-bipyridine]-6-yl)-3-methyl-imidazo[1,2-a]pyridin-8-amine；2-(2-chlorophenyl)-N-(2-methoxy-2'-methyl[3,4'-bipyridin]-6-yl)-3-methyl-imidazo[1,2-a]pyridin-8-amine；2-(2-chlorophenyl)-N-[6-methoxy-5-(2-methylpyridin-4-yl)pyridin-2-yl]-3-methylimidazo[1,2-a]pyridin-8-amine
• CAS: 1239719-36-8
• 化学式: C₂₆H₂₂ClN₅O
• 分子量: 455.947
• InChiKey: QNWSEGVTGQBGCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  64.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• NOVEL SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS GAMMA SECRETASE MODULATORS
  申请人：CELLZOME LIMITED

  公开号：US20150094311A1

  公开（公告）日：2015-04-02

  The present invention is concerned with substituted bicyclic heterocyclic compounds of Formula (I) wherein Het 1 , Het 2 , A 1 , A 2 , A 3 and A 4 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
• US8946426B2
  申请人：——

  公开号：US8946426B2

  公开（公告）日：2015-02-03