6α-methylcholest-4-en-3-one | 43217-62-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 6α-methylcholest-4-en-3-one
• 英文别名: 6α-methyl-cholest-4-en-3-one；6α-Methyl-cholest-4-en-3-on；6α-Methyl-cholesten-(4)-on-(3)；6α-methyl-4-cholesten-3-one；6α-Methyl-Δ⁴-cholesten-3-on；(6S,8S,9S,10R,13R,14S,17R)-6,10,13-trimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
• CAS: 43217-62-5
• 化学式: C₂₈H₄₆O
• 分子量: 398.673
• InChiKey: IVFPMYMFWFNLID-OIKQIUDJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  6α-methylcholest-4-en-3-one 在 吡啶 、 lithium tri-t-butoxyaluminum hydride 作用下， 以 四氢呋喃 为溶剂， 生成 3β-Acetoxy-6α-methyl-cholesten-(4)
  参考文献：
  名称：

  Julia,S.; Decouvelaere,B., Bulletin de la Societe Chimique de France, 1963, p. 2476 - 2480

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 环己酮 、 aluminum isopropoxide 作用下， 生成 6α-methylcholest-4-en-3-one
  参考文献：
  名称：

  Further Structural Evidence for the Reaction Product of Cholesterol-α-oxide and Methylmagnesium Iodide

  摘要：

  DOI：

  10.1021/ja01141a043

文献信息

• The Photo-Beckmann Rearrangement of Steroidal β,γ-Unsaturated Ketone Oximes
  作者：Hiroshi Suginome、Norio Maeda、Yuko Takahashi、Nobuyoshi Miyata

  DOI：10.1246/bcsj.54.846

  日期：1981.3

  The photoreaction of 4,4-dimethylcholest-5-en-3-one oxime, a β,γ-unsaturated ketone oxime, has given two lactams, 4a,4a-dimethyl-3-aza-A-homocholest-5-en-4-one and 4a,4a-dimethyl-4-aza-A-homocholest-5-en-3-one resulting from photo-Beckmann rearrangement. 4,4,6-Trimethylcholest-5-en-3-one oxime behaved analogously on photolysis, yielding two lactams but accompanied by 4,6-dimethyl-4-methylene-3,4-s

  4,4-二甲基胆甾醇-5-en-3-one肟（一种β,γ-不饱和酮肟）的光反应产生了两种内酰胺，4a,4a-二甲基-3-氮杂-A-homocholest-5-en- 4-one 和 4a,4a-dimethyl-4-aza-A-homocholest-5-en-3-one 由 photo-Beckmann 重排产生。4,4,6-Trimethylcholest-5-en-3-one 肟在光解时表现类似，产生两种内酰胺，但伴随着 4,6-二甲基-4-亚甲基-3,4-secoccholest-5-ene-3-腈作为次要产品。相比之下，普通贝克曼重排的主要产物是二阶贝克曼重排产生的腈。
• PHOTOCHEMICAL TRANSFORMATIONS OF DIENES. III. THE PHOTOLYSIS OF 3- AND 3,6-SUBSTITUTED CHOLESTA-3,5-DIENES
  作者：Clifford C. Leznoff、George Just

  DOI：10.1139/v64-436

  日期：1964.12.1

  not available

  不可用
• Further Structural Evidence for the Reaction Product of Cholesterol-α-oxide and Methylmagnesium Iodide
  作者：Richard B. Turner

  DOI：10.1021/ja01141a043

  日期：1952.11
• US4100027A
  申请人：——

  公开号：US4100027A

  公开（公告）日：1978-07-11
• Interlocking Directorates: An Example of Tacit Knowledge Transfer
  作者：Sean O'Hagan、Milford B. Green

  DOI：10.2747/0272-3638.23.2.154

  日期：2002.3

  This paper illustrates tacit knowledge flows between American and Canadian metropolitan areas. Using the spatial distribution of interlocking in Canada and the United States a spatial component is added to the resource dependency paradigm. Using a poisson regression model. components of cities that initiate and attract interlocking, and thus knowledge transfer, can be identified. From the results, the authors propose the concept of a "knowledge threshold" essential for the transfer of tacit knowledge. In Canada the "knowledge threshold" encompasses the entire country while it is more regionally based in the United States.