1,1-diethoxy-4-phenylbutan-2-one | 96952-94-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1-diethoxy-4-phenylbutan-2-one
• 英文别名: 1,1-Diaethoxy-4-phenyl-butanon-(2)；δ.δ-Diaethoxy-γ-oxo-α-phenyl-butan；1,1-Diaethoxy-4-phenyl-butan-2-on；1,1-Diethoxy-4-phenylbutan-2-one
• CAS: 96952-94-2
• 化学式: C₁₄H₂₀O₃
• 分子量: 236.311
• InChiKey: BSJTVOCIXVZTJF-UHFFFAOYSA-N

物化性质

• 沸点：
  142-145 °C(Press: 10 Torr)
• 密度：
  1.020±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,1-diethoxy-4-phenylbutan-2-one 在 盐酸 、 硫酸 作用下， 以 乙醇 、 水 为溶剂， 反应 4.0h， 生成 8-benzyl-6-hydroxyphenyl-2-(2-phenylethyl)imidazo<1,2-a>pyrazin-3-one
  参考文献：
  名称：

  Qi, Chen Feng; Gomi, Yasushiro; Hirano, Takashi, Journal of the Chemical Society. Perkin transactions I, 1992, # 13, p. 1607 - 1612

  摘要：

  DOI：
• 作为产物：
  描述：

  2,2-二乙氧基乙酸乙酯 在 氢氧化钾 、 乙醇 、 sodium ethanolate 、 sodium 作用下， 生成 1,1-diethoxy-4-phenylbutan-2-one
  参考文献：
  名称：

  Density and Water Exchange-Dependent Growth and Survival of Litopenaeus setiferus Postlarvae

  摘要：

  AbstractThis present study was designed to investigate the effects of stocking density and water exchange on the growth rate, survival and performance index of L. setiferus postlarvae under controlled laboratory conditions. The experiment was done with postlarvae (PL10 to PL40) at densities of 50, 150, 250 and 350 shrimp/m2 and various different water exchanges rate per day (0, 6, 12 and 18%). The maximum growth rate was obtained for shrimp with 12% water exchange per day at all densities. A reduction of the maximum growth rate was observed in relation to density with the highest values in shrimp stocked in a density of 50 and 150 shrimp/m2 (mean value of 0.53 mg/d) and the lowest in shrimp stocked in a density of 350 shrimp/m2 (0.24 mg/d). The multiple regression equation obtained to relate performance index (growth rate* survival : PI), shrimp density (X1) and water exchange (X2) was: PI = 0.31 + (0.001) X1+ 0.039 X2+ 2.28 × 10−6 X12+ (−0.0017) X22+ (0.000026)X1X2,R2= 0.78; P > 0.03. According to this equation the optimum shrimp density‐water exchange comhination was between 5 to 12% of water exchange at stocking density of between 50 and 150 shrimp/m2. Salinity, ammonia‐N and nitrite‐N increased according to the time spent in tanks without water exchange. With no (0%) water exchange, water quality parameters measured were outside the optimum for L. setiferus postlarvae. The use of optimum density and water exchange in a nursery system for L. setiferus with optimum variables established is proposed.

  DOI：

  10.1111/j.1749-7345.2001.tb01091.x

文献信息

• A Scalable Metal‐, Azide‐, and Halogen‐Free Method for the Preparation of Triazoles
  作者：Peter R. Clark、Glynn D. Williams、Jerome F. Hayes、Nicholas C. O. Tomkinson

  DOI：10.1002/anie.201915944

  日期：2020.4.20

  α-ketoacetals, tosyl hydrazide, and a primary amine. Functional group tolerance is outstanding in both the α-ketoacetal and amine coupling partners providing access to 4-, 1,4-, 1,5-, and 1,4,5- substituted triazoles in excellent yield. This robust method results in densely functionalised 1,2,3-triazoles that remain challenging to prepare by azide-alkyne cycloaddition (AAC, CuAAC, RuAAC) methods and can be scaled

  已开发出一种可扩展的，无金属，无叠氮化物和无卤素的方法，用于合成取代的1,2,3-三唑。该反应通过α-酮缩醛，甲苯磺酰脲和伯胺的3组分偶联而进行。在α-酮缩醛和胺偶合伙伴中，官能团的耐受性均十分出色，从而能够以优异的产率获得4-，1,4-，1,5-和1,4,5-取代的三唑。这种稳健的方法导致了稠密官能化的1,2,3-三唑，这些化合物仍然难以通过叠氮化物-炔烃环加成（AAC，CuAAC，RuAAC）方法制备，并且可以在间歇式或流式反应器中进行规模化。还描述了脂族胺或苯胺的化学选择性反应的方法，揭示了这种新颖且用途广泛的转化的一些潜力。
• Organocatalytic asymmetric biomimetic transamination of α-keto acetals to chiral α-amino acetals
  作者：Hongjie Pan、Ying Xie、Mao Liu、Yian Shi

  DOI：10.1039/c3ra42906g

  日期：——

  This paper describes a chiral base-catalyzed asymmetric biomimetic transamination of α-keto acetals. A wide variety of α-amino acetals containing various functional groups can be synthesized in 50–85% yield and 82–86% ee.

  本文描述了α-酮缩醛的手性碱催化的不对称仿生转氨作用。可以合成各种含各种官能团的α-氨基乙缩醛，产率为50-85％，ee为82-86％。
• Qi, Chen Feng; Gomi, Yasushiro; Hirano, Takashi, Journal of the Chemical Society. Perkin transactions I, 1992, # 13, p. 1607 - 1612
  作者：Qi, Chen Feng、Gomi, Yasushiro、Hirano, Takashi、Ohashi, Mamoru、Ohmiya, Yoshihiro、Tsuji, Frederick I.

  DOI：——

  日期：——
• Density and Water Exchange-Dependent Growth and Survival of Litopenaeus setiferus Postlarvae
  作者：Gabriela Palomino、Fabian Contreras、Adolfo Sanchez、Carlos Rosas

  DOI：10.1111/j.1749-7345.2001.tb01091.x

  日期：2001.6

  AbstractThis present study was designed to investigate the effects of stocking density and water exchange on the growth rate, survival and performance index of L. setiferus postlarvae under controlled laboratory conditions. The experiment was done with postlarvae (PL10 to PL40) at densities of 50, 150, 250 and 350 shrimp/m2 and various different water exchanges rate per day (0, 6, 12 and 18%). The maximum growth rate was obtained for shrimp with 12% water exchange per day at all densities. A reduction of the maximum growth rate was observed in relation to density with the highest values in shrimp stocked in a density of 50 and 150 shrimp/m2 (mean value of 0.53 mg/d) and the lowest in shrimp stocked in a density of 350 shrimp/m2 (0.24 mg/d). The multiple regression equation obtained to relate performance index (growth rate* survival : PI), shrimp density (X1) and water exchange (X2) was: PI = 0.31 + (0.001) X1+ 0.039 X2+ 2.28 × 10−6 X12+ (−0.0017) X22+ (0.000026)X1X2,R2= 0.78; P > 0.03. According to this equation the optimum shrimp density‐water exchange comhination was between 5 to 12% of water exchange at stocking density of between 50 and 150 shrimp/m2. Salinity, ammonia‐N and nitrite‐N increased according to the time spent in tanks without water exchange. With no (0%) water exchange, water quality parameters measured were outside the optimum for L. setiferus postlarvae. The use of optimum density and water exchange in a nursery system for L. setiferus with optimum variables established is proposed.