nitrooxybutyl 5-ethyl-2-(2',3',5',6'-tetrafluoroanilino)phenylacetate | 1100398-60-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: nitrooxybutyl 5-ethyl-2-(2',3',5',6'-tetrafluoroanilino)phenylacetate
• 英文别名: 4-Nitrooxybutyl 2-[5-ethyl-2-(2,3,5,6-tetrafluoroanilino)phenyl]acetate
• CAS: 1100398-60-4
• 化学式: C₂₀H₂₀F₄N₂O₅
• 分子量: 444.383
• InChiKey: GBFRRPGESIQPLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  31
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  93.4
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• [EN] CERTAIN 5-ALKYL-2-ARYLAMINOPHENYLACETIC ACIDS AND DERIVATIVES<br/>[FR] CERTAINS ACIDES 5-ALKYL-2-ARYLAMINOPHENYLACETIQUES ET LEURS DERIVES
  申请人：NOVARTIS AG

  公开号：WO1999011605A1

  公开（公告）日：1999-03-11

  Disclosed are the compounds of formula (I), wherein R is methyl or ethyl; R1 is chloro or fluoro; R2 is hydrogen or fluoro; R3 is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or hydroxy; R4 is hydrogen or fluoro; and R5 is chloro, fluoro, trifluoromethyl or methyl; pharmaceutically acceptable salts thereof; and pharmaceutically acceptable prodrug esters thereof; as selective COX-2 cyclooxygenase inhibitors.

  本发明涉及式（I）的化合物，其中R为甲基或乙基；R1为氯或氟；R2为氢或氟；R3为氢、氟、氯、甲基、乙基、甲氧基、乙氧基或羟基；R4为氢或氟；R5为氯、氟、三氟甲基或甲基；其药学上可接受的盐；及其药学上可接受的前药酯，作为选择性COX-2环氧化酶抑制剂。
• Certain 5-alkyl-2-arylaminophenylacetic acids and derivatives
  申请人：——

  公开号：US20020183391A1

  公开（公告）日：2002-12-05

  Disclosed are the compounds of formula I 1 wherein R is methyl or ethyl; R 1 is chloro or fluoro; R 2 is hydrogen or fluoro; R 3 is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or hydroxy; R 4 is hydrogen or fluoro; and R 5 is chloro, fluoro, trifluoromethyl or methyl; and pharmaceutically acceptable salts thereof, as selective COX-2 cyclooxygenase inhibitors; and pharmaceutically acceptable prodrug esters thereof.

  公开了I1式化合物，其中R为甲基或乙基；R1为氯或氟；R2为氢或氟；R3为氢、氟、氯、甲基、乙基、甲氧基、乙氧基或羟基；R4为氢或氟；R5为氯、氟、三氟甲基或甲基；以及其药学上可接受的盐，作为选择性COX-2环氧化酶抑制剂；以及其药学上可接受的前药酯。
• Certain 5-alkyl-2arylaminophenylacetic acids and derivatives
  申请人：——

  公开号：US20020013369A1

  公开（公告）日：2002-01-31

  Disclosed are the compounds of formula I 1 wherein R is methyl or ethyl; R 1 is chloro or fluoro; R 2 is hydrogen or fluoro; R 3 is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or hydroxy; R 4 is hydrogen or fluoro; and R 5 is chloro, fluoro, trifluoromethyl or methyl; and pharmaceutically acceptable salts thereof, as selective COX-2 cyclooxygenase inhibitors; and pharmaceutically acceptable prodrug esters thereof.

  本发明涉及一种化合物，其化学式为I1，其中R为甲基或乙基；R1为氯或氟；R2为氢或氟；R3为氢、氟、氯、甲基、乙基、甲氧基、乙氧基或羟基；R4为氢或氟；R5为氯、氟、三氟甲基或甲基；以及其药学上可接受的盐，作为选择性COX-2环氧化酶抑制剂；以及其药学上可接受的前药酯。
• CERTAIN 5-ALKYL-2-ARYLAMINOPHENYLACETIC ACIDS AND DERIVATIVES
  申请人：Novartis AG

  公开号：EP1007505A1

  公开（公告）日：2000-06-14
• US6291523B1
  申请人：——

  公开号：US6291523B1

  公开（公告）日：2001-09-18