SKF83566氢溴酸盐 | 108179-91-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 中文名称: SKF83566氢溴酸盐
• 英文名称: SKF 83566 hydrobromide
• 英文别名: 8-bromo-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol;hydrobromide
• CAS: 108179-91-5
• 化学式: C17H19Br2NO
• 分子量: 413.1
• InChiKey: SDQJYYGODYRPBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.35
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  23.5
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Method for post mortem diagnosis of Alzheimer's Disease (AD)
  申请人：Red Bull GmbH

  公开号：EP2806276A1

  公开（公告）日：2014-11-26

  Disclosed is a method for diagnosing Alzheimer's Disease (AD) post mortem, wherein the amount of at least one receptor complex, selected from the group consisting of nicotinic acetylcholine receptor complex 4, nicotinic acetylcholine receptor complex 7, dopamine receptor complex D1 and dopamine receptor complex D2, is measured in a brain sample of a patient and diagnosing AD, if the amount of the complex in the sample is increased compared to normal, non-AD levels.

  本发明公开了一种用于死后诊断阿尔茨海默病（AD）的方法，该方法测量患者脑样本中至少一种受体复合物的含量，这些受体复合物选自由烟碱乙酰胆碱受体复合物 4、烟碱乙酰胆碱受体复合物 7、多巴胺受体复合物 D1 和多巴胺受体复合物 D2 组成的组，如果样本中的复合物含量与正常非 AD 水平相比有所增加，则诊断为 AD。
• Targeting cell tropism receptors to inhibit cytomegalovirus infection
  申请人：UNIVERSITY OF MASSACHUSETTS

  公开号：US11484570B2

  公开（公告）日：2022-11-01

  Methods for treating or reducing the risk of a cytomegalovirus infection in a subject that include administering one or more of an inhibitor of Deleted in Malignant Brain Tumors 1 (DMBT1), an inhibitor of OR14I1, or an inhibitor of adenylyl cyclases.

  治疗或降低受试者巨细胞病毒感染风险的方法，包括施用恶性脑肿瘤删减1（DMBT1）抑制剂、OR14I1抑制剂或腺苷酸环化酶抑制剂中的一种或多种。
• TARGETING CELL TROPISM RECEPTORS TO INHIBIT CYTOMEGALOVIRUS INFECTION
  申请人：University of Massachusetts

  公开号：EP3609521A1

  公开（公告）日：2020-02-19
• Elimination of chronic pain by chronic activation of adenosine receptor type A1 in peripheral sensory neurons
  申请人：University of Rochester

  公开号：US20200276312A1

  公开（公告）日：2020-09-03

  The present invention provides compositions and methods for treating chronic pain.
• Targeting Cell Tropism Receptors to Inhibit Cytomegalovirus Infection
  申请人：UNIVERSITY OF MASSACHUSETTS

  公开号：US20200376077A1

  公开（公告）日：2020-12-03

  Methods for treating or reducing the risk of a cytomegalovirus infection in a subject that include administering one or more of an inhibitor of Deleted in Malignant Brain Tumors 1 (DMBT1), an inhibitor of OR14I1, or an inhibitor of adenylyl cyclases.