4-氨基-5-氯-N-[2-[环丙基(甲基)氨基]乙基]-2-甲氧基苯甲酰胺 | 126105-17-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-氨基-5-氯-N-[2-[环丙基(甲基)氨基]乙基]-2-甲氧基苯甲酰胺
• 中文别名: 4-氨基-5-氯-N-{2-[环丙基(甲基)氨基]乙基}-2-甲氧基苯酰胺
• 英文名称: 2-methoxy-4-amino-5-chloro-N-(2-(methylcyclopropylamino)ethyl)-benzamide
• 英文别名: Benzamide, 4-amino-5-chloro-N-(2-(cyclopropylmethylamino)ethyl)-2-methoxy-；4-amino-5-chloro-N-[2-[cyclopropyl(methyl)amino]ethyl]-2-methoxybenzamide
• CAS: 126105-17-7
• 化学式: C₁₄H₂₀ClN₃O₂
• 分子量: 297.785
• InChiKey: HBWNVHHLPLJDRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  67.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-氨基-5-氯-2-甲氧基苯甲酸 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 4-氨基-5-氯-N-[2-[环丙基(甲基)氨基]乙基]-2-甲氧基苯甲酰胺
  参考文献：
  名称：

  Synthesis and preliminary data on new selective and potent gastric prokinetic substituted benzamides

  摘要：

  A series of amino-halogen-N-[2-aminoethyl] benzamides was synthesized and evaluated for enhancing gastric emptying. Compared to metoclopramide, domperidone and bromopride, a number of compounds were shown to be more active in enhancing gastric motility (rat stomach emptying), devoid of dopaminergic D2-receptor antagonism (rat apomorphine test) and to be less toxic.

  DOI：

  10.1016/0223-5234(93)90129-3

文献信息

• N-cycloalkylaminoethylbenzamide derivatives, their synthesis and pharmaceutical preparations
  申请人：POLI INDUSTRIA CHIMICA S.p.A.

  公开号：EP0333073A3

  公开（公告）日：1990-09-12

  New N-(2-cycloalkylamino)ethyl-substituted benzami­des having a powerful stimulating activity on the gastric motility and with a low central anti-dopaminergic activity are described. The synthesis and the pharmaceutical preparations for therapeutical use are also described.

  本文描述了一种具有强烈促进胃动力作用和低中枢抗多巴胺能活性的新型N-(2-环烷基氨基)乙基取代苯甲酰胺。同时还描述了其合成和制备用于治疗的药物制剂。
• US5010108A
  申请人：——

  公开号：US5010108A

  公开（公告）日：1991-04-23
• Synthesis and preliminary data on new selective and potent gastric prokinetic substituted benzamides
  作者：L Del Corona、G Signorelli、A Pinzetta、G Coppi

  DOI：10.1016/0223-5234(93)90129-3

  日期：1993.1

  A series of amino-halogen-N-[2-aminoethyl] benzamides was synthesized and evaluated for enhancing gastric emptying. Compared to metoclopramide, domperidone and bromopride, a number of compounds were shown to be more active in enhancing gastric motility (rat stomach emptying), devoid of dopaminergic D2-receptor antagonism (rat apomorphine test) and to be less toxic.