(3-cloro-2-fluorophenyl)-(4-methoxy-2-methylphenyl)-methanone | 680610-63-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-cloro-2-fluorophenyl)-(4-methoxy-2-methylphenyl)-methanone
• 英文别名: [2-fluoro-3-chlorophenyl](4-methoxy-2-methylphenyl)methanone；(3-chloro-2-fluorophenyl)-(4-methoxy-2-methylphenyl)methanone
• CAS: 680610-63-3
• 化学式: C₁₅H₁₂ClFO₂
• mdl: MFCD21509446
• 分子量: 278.71
• InChiKey: QTTUIZQHSAMOIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.133
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (3-cloro-2-fluorophenyl)-(4-methoxy-2-methylphenyl)-methanone 、 一水合肼 在 4-二甲氨基吡啶 作用下， 以to give the product (0.613 g) as a yellow solid的产率得到7-chloro-3-(4-methoxy-2-methylphenyl)-1H-indazole
  参考文献：
  名称：

  Indazoles useful in treating cardiovascular diseases

  摘要：

  这项发明提供了I式或Ia式化合物：它们可用于治疗或抑制LXR介导的疾病。

  公开号：

  US20060030612A1

文献信息

• PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS
  申请人：Gilead Sciences, Inc.

  公开号：US20140039194A1

  公开（公告）日：2014-02-06

  The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting properties.

  这项发明提供了一种合成过程和合成中间体，可用于制备具有有用整合酶抑制性能的4-氧喹啉化合物。
• [EN] SUBSTITUTED 4-(INDAZOL-3-YL)PHENOLS AS ESTROGEN RECEPTOR (ER) LIGANDS AND THEIR USE IN THE TREATMENT OF INFLAMMATORY DISEASES<br/>[FR] 4-(INDAZOL-3-YL)PHENOLS SUBSTITUES COMME LIGANDS DU RECEPTEUR DES OESTROGENES ET LEUR UTILISATION DANS LE TRAITEMENT DE MALADIES INFLAMMATOIRES
  申请人：WYETH CORP

  公开号：WO2004031159A1

  公开（公告）日：2004-04-15

  This invention provides compound of formulae I or II having the structure wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined in the specification or a pharmaceutically acceptable salt thereof which are useful for the treatment of the inflammatory component of diseases and are particularly useful in treating atherosclerosis, myocardial infarction, congestive heart failure, inflammatory bowel disease. Arthritis, type II diabetes, and autoimmune diseases such as multiple sclerosis and rheumatiod arthritis.

  这项发明提供了具有结构的化合物I或II的公式，其中R1、R2、R3、R4、R5、R6、R7、R8、R9和R10如规范中定义，或其药用盐，这些化合物对治疗疾病的炎症成分有用，特别适用于治疗动脉粥样硬化、心肌梗死、充血性心力衰竭、炎症性肠病、关节炎、2型糖尿病以及多发性硬化和类风湿关节炎等自身免疫疾病。
• Substituted 4-(indazol-3-yl)phenols
  申请人：Wyeth

  公开号：US20040167127A1

  公开（公告）日：2004-08-26

  This invention provides compound of formulae I or II having the structure 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are as defined in the specification or a pharmaceutically acceptable salt thereof which are useful for the treatment of the inflammatory component of diseases and are particularly useful in treating atherosclerosis, myocardial infarction, congestive heart failure, inflammatory bowel disease, arthritis, type II diabetes, and autoimmune diseases such as multiple sclerosis and rheumatiod arthritis.

  本发明提供了式I或式II的化合物，其结构为1，其中R1、R2、R3、R4、R5、R6、R7、R8、R9和R10如规范中所定义，或其药学上可接受的盐，其对于疾病的炎症成分具有治疗作用，尤其是在治疗动脉粥样硬化、心肌梗死、充血性心力衰竭、炎症性肠病、关节炎、2型糖尿病以及自身免疫性疾病如多发性硬化和类风湿性关节炎方面特别有用。
• Substituted 4-(Indazol-3-yl)phenols
  申请人：Steffan J. Robert

  公开号：US20070225349A1

  公开（公告）日：2007-09-27

  This invention provides compound of formulae I or II having the structure wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are as defined in the specification or a pharmaceutically acceptable salt thereof which are useful for the treatment of the inflammatory component of diseases and are particularly useful in treating atherosclerosis, myocardial infarction, congestive heart failure, inflammatory bowel disease, arthritis, type II diabetes, and autoimmune diseases such as multiple sclerosis and rheumatiod arthritis.

  该发明提供了式I或II的化合物，其结构为： 其中R1、R2、R3、R4、R5、R6、R7、R8、R9和R10如规范中所定义，或其药学上可接受的盐，用于治疗疾病的炎症成分，特别适用于治疗动脉硬化、心肌梗塞、充血性心力衰竭、炎症性肠病、关节炎、II型糖尿病以及多发性硬化和风湿性关节炎等自身免疫疾病。
• Indazoles
  申请人：Wyeth

  公开号：US07592363B2

  公开（公告）日：2009-09-22

  This invention provides compounds of Formula (I) or (Ia): that are useful in the treatment or inhibition of LXR mediated diseases.

  该发明提供了公式(I)或(Ia)的化合物：它们在治疗或抑制LXR介导的疾病方面是有用的。