2-(2,2-difluoroethoxy)pyridine-4-carboxylic acid | 1423029-44-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(2,2-difluoroethoxy)pyridine-4-carboxylic acid
• CAS: 1423029-44-0
• 化学式: C₈H₇F₂NO₃
• mdl: MFCD22628441
• 分子量: 203.145
• InChiKey: GDMRWLQOPXWFJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  59.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-(2,2-difluoroethoxy)pyridine-4-carboxylic acid 在 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 N-甲基吡咯烷酮 、 二氯甲烷 为溶剂， 反应 7.0h， 生成 3-chloro-1-[(cyanomethyl)amino]-6-[2-(2,2-difluoroethoxy)pyridine-4-carbonyl]-5,6,7,8-tetrahydro-2,6-naphthyridine-4-carbonitrile
  参考文献：
  名称：

  [EN] 5,6,7,8-TETRAHYDRO-2,6- AND 2,7-NAPHTHYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF DISEASES RESPONSIVE TO CITRATE TRANSPORTER MODULATION
  [FR] DÉRIVÉS DE 5,6,7,8-TÉTRAHYDRO-2,6- ET 2,7-NAPHTYRIDINE DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE MALADIES SENSIBLES À LA MODULATION DU TRANSPORTEUR DE CITRATE

  摘要：

  The invention relates to a compound according to general formula (I), which acts as an inhibitor of a citrate transporter, e.g. a sodium-coupled citrate transporter such as INDY (SLC13A5); to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament as well as the use in the treatment and/or prevention of a condition associated with the activity of a citrate transporter such as metabolic diseases and age related diseases.

  公开号：

  WO2023285583A1