N⁴-pentyl-pyrimidine-4,6-diyldiamine | 99182-28-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N⁴-pentyl-pyrimidine-4,6-diyldiamine
• 英文别名: N⁴-Pentyl-pyrimidin-4,6-diyldiamin；N4-pentylpyrimidine-4,6-diamine；4-N-pentylpyrimidine-4,6-diamine
• CAS: 99182-28-2
• 化学式: C₉H₁₆N₄
• 分子量: 180.253
• InChiKey: GJAWWIONVYVMGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  63.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• New agents for the treatment of cancer
  申请人：Medizinische Universität Wien

  公开号：EP2924045A1

  公开（公告）日：2015-09-30

  The invention relates to compounds comprising a Co3+ ion and a tyrosine kinase inhibitor moiety, wherein the tyrosine kinase inhibitor moiety comprises a Co3+-chelating moiety and wherein the tyrosine kinase inhibitor moiety is a 4-anilinoquinazoline tyrosine kinase inhibitor moiety. The 4-anilinoquinazoline tyrosine kinase inhibitor moiety has the general formula B, wherein R1, R2, R3 and m are as defined herein. The compounds are useful in the treatment of hyperproliferative diseases, such as cancer.

  本发明涉及一种化合物，包括Co3+离子和酪氨酸激酶抑制剂基团，其中酪氨酸激酶抑制剂基团包括Co3+螯合基团，且酪氨酸激酶抑制剂基团是4-苯胺基喹唑啉酪氨酸激酶抑制剂基团。4-苯胺基喹唑啉酪氨酸激酶抑制剂基团具有通式B，其中R1、R2、R3和m的定义如本文所述。该化合物在治疗高增殖性疾病，如癌症方面有用。
• [EN] NEW AGENTS FOR THE TREATMENT OF CANCER<br/>[FR] NOUVEAUX AGENTS POUR LE TRAITEMENT DU CANCER
  申请人：UNIV WIEN MED

  公开号：WO2015144759A1

  公开（公告）日：2015-10-01

  The invention relates to prodrug compounds comprising a Co3+ ion and aquinazoline tyrosine kinase inhibitor moiety, wherein the quinazoline tyrosine kinase inhibitor moiety comprises a Co3+ -chelating moiety and wherein the quinazoline tyrosine kinase inhibitor moiety is a 4-anilinoquinazoline tyrosine kinase inhibitor moiety. The 4-anilinoquinazoline tyrosine kinase inhibitor moiety has the general formula B,wherein R1, R2, R3 and m are as defined herein. The compounds are useful in the treatment of hyperproliferative diseases, such as cancer.