2-propyl-5-trifluoromethoxybenzimidazole | 1392475-47-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-propyl-5-trifluoromethoxybenzimidazole
• 英文别名: 1H-Benzimidazole, 2-propyl-6-(trifluoromethoxy)-；2-propyl-6-(trifluoromethoxy)-1H-benzimidazole
• CAS: 1392475-47-6
• 化学式: C₁₁H₁₁F₃N₂O
• 分子量: 244.216
• InChiKey: BARRQIDGFMTMQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  37.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• DOT1L INHIBITORS FOR USE IN THE TREATMENT OF LEUKEMIA
  申请人：Epizyme, Inc.

  公开号：US20200113923A1

  公开（公告）日：2020-04-16

  The present invention relates to DOT1L inhibitors. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
• SUBSTITUTED PURINE AND 7-DEAZAPURINE COMPOUNDS
  申请人：Epizyme, Inc.

  公开号：US20210252035A1

  公开（公告）日：2021-08-19

  The present invention relates to substituted purine and 7-deazapurine compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer and neurological disorders, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
• US8242284B1
  申请人：——

  公开号：US8242284B1

  公开（公告）日：2012-08-14
• US8293780B1
  申请人：——

  公开号：US8293780B1

  公开（公告）日：2012-10-23