methyl 6-chloro-2-(pyridin-3-yl)pyrimidine-4-carboxylate | 1244018-36-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: methyl 6-chloro-2-(pyridin-3-yl)pyrimidine-4-carboxylate
• 英文别名: Methyl 6-chloro-2-(3-pyridinyl)-4-pyrimidinecarboxylate；methyl 6-chloro-2-pyridin-3-ylpyrimidine-4-carboxylate
• CAS: 1244018-36-7
• 化学式: C₁₁H₈ClN₃O₂
• 分子量: 249.656
• InChiKey: XXZGGVYOBOPDRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  65
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS<br/>[FR] DÉRIVÉS DE L'ACIDE HYDROXAMIQUE EN TANT QU'AGENTS CONTRE DES BACTÉRIES À GRAM NÉGATIF
  申请人：ASTRAZENECA AB

  公开号：WO2010100475A1

  公开（公告）日：2010-09-10

  The invention relates to chemical compounds of formula (IB): or a salt thereof. In some embodiments, the invention relates to inhibitors of UDP-3-0 — (R-S-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC). In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein and their use in the prevention and/or treatment of Gram- negative bacterial infections.

  该发明涉及化学式(IB)的化合物或其盐。在某些实施例中，该发明涉及UDP-3-0-(R-S-羟基肉豆蔻酰)-N-乙酰葡萄糖胺脱乙酰酶(LpxC)的抑制剂。在更进一步的实施例中，该发明涉及包含本文披露的化合物的药物组合物及其在预防和/或治疗革兰氏阴性细菌感染中的用途。
• CHEMICAL COMPOUNDS
  申请人：Syngenta Limited

  公开号：EP2303015A2

  公开（公告）日：2011-04-06
• [EN] CHEMICAL COMPOUNDS<br/>[FR] COMPOSÉS CHIMIQUES
  申请人：SYNGENTA LTD

  公开号：WO2009138712A2

  公开（公告）日：2009-11-19

  The present invention relates to substituted pyrimidine derivatives as well as N- oxides and agriculturally acceptable salts thereof, and their use to control undesired plant growth, in particular in crops of useful plants. The invention extends to herbicidal compositions comprising such compounds, N-oxides and/or salts as well as mixtures of the same with one or more further active ingredient (such as, for example, an herbicide, fungicide, insecticide and/or plant growth regulator) and/or a safener.