2,2,5,5-tetramethyl-9-(2',5'-dimethoxyphenyl)-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione | 405152-27-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2,5,5-tetramethyl-9-(2',5'-dimethoxyphenyl)-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione
• 英文别名: 9-(2,5-dimethoxyphenyl)-3,3,6,6-tetramethyl-3,4,6,7-tetrahydro-2H-xanthene-1,8(5H,9H)-dione；9-(2,5-Dimethoxyphenyl)-3,3,6,6-tetramethyl-2,3,4,5,6,7,8,9-octahydro-1H-xanthene-1,8-dione；9-(2,5-dimethoxyphenyl)-3,3,6,6-tetramethyl-4,5,7,9-tetrahydro-2H-xanthene-1,8-dione
• CAS: 405152-27-4
• 化学式: C₂₅H₃₀O₅
• mdl: MFCD00604297
• 分子量: 410.51
• InChiKey: QZNQOJAROOGMCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5,5-二甲基-1,3-环己二酮 、 2,5-二甲氧基苯甲醛 在 12-tungestophosphoric acid immobilized on magnetite graphene oxide 作用下， 以 水 为溶剂， 反应 0.33h， 以84%的产率得到2,2,5,5-tetramethyl-9-(2',5'-dimethoxyphenyl)-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione
  参考文献：
  名称：

  两种新的磁性纳米复合材料石墨烯和12-tungesto磷酸：绿色合成1,8-二氧羰基八氢氧杂蒽的表征和催化性能的比较

  摘要：

  通过共沉淀和共沉淀-溶剂热法合成了固定在磁铁矿氧化石墨烯（Fe 3 O 4 / GO / PW）和磁铁矿石墨气凝胶（Fe 3 O 4 / GA / PW）上的两种分散良好的H 3 PW 12 O 40，分别。在水中合成1,8-二氧-八氢氧杂蒽（DOX）时，比较了两种制备的催化剂的催化活性，浸出和可循环利用性。与Fe 3 O 4 / GA / PW相比，Fe 3 O 4 / GO / PW表现出更高的活性，并且浸出率更低，再利用次数更高。制备的铁3 O 4 / GO / PW纳米复合材料的特征在于透射电子显微镜，扫描电子显微镜，振动样品磁力计，能量色散X射线光谱，X射线衍射，激光粒度分析仪，傅立叶变换红外光谱，Brunauer–Emmett –Teller（BET）和电感耦合等离子体原子发射光谱（ICP-AES）。优异的转化率表明该催化剂已用作合成DOX的高效催化剂。该催化剂的新颖之处在于，

  DOI：

  10.1039/c6ra02934e

文献信息

• Reaction in Dry Media: Silica Gel Supported Ferric Chloride Catalyzed Synthesis of 1,8-Dioxo-octahydroxanthene Derivatives
  作者：Hamid Reza Shaterian、Asghar Hosseinian、Majid Ghashang

  DOI：10.1080/10426500802066096

  日期：2008.11.7

  3 -SiO 2 as an efficient and heterogeneous catalyst under microwave irradiation and thermal conditions. This method has the advantages of high yields, cleaner reactions, efficient and cost-effective method, simple methodology, short reaction times, easy workup, and greener conditions.

  在此，我们描述了一种在微波辐射和热条件下，在 FeCl 3 -SiO 2 作为高效多相催化剂的情况下，通过二甲酮和取代苯甲醛缩合制备 1,8-二氧代-八氢氧杂蒽衍生物的绿色程序. 该方法具有收率高、反应更清洁、方法高效且经济、方法简单、反应时间短、后处理容易、条件更环保等优点。
• Grafting of sulphamic acid on functionalized sawdust: A novel solid acid catalyst for the synthesis of 1,8-dioxo-octahydroxanthenes
  作者：Shrikrishna Karhale

  DOI：10.1007/s11164-020-04136-5

  日期：2020.6

  Abstract A solid acid catalyst bearing sulphamic acid on sawdust (SA@Sawdust) was designed as a novel heterogeneous catalyst. The structure of prepared catalyst was assessed by various spectroscopic techniques such as FT-IR, field emission scanning electron microscopy and energy dispersive X-ray, thermogravimetric analysis, solid-state CP/MAS 13C-NMR spectroscopy, and CHNS analysis. The efficiency

  摘要 设计了一种在木屑上带有氨基磺酸的固体酸催化剂（SA @ Sawdust）作为新型多相催化剂。制备的催化剂的结构通过各种光谱技术进行了评估，例如FT-IR，场发射扫描电子显微镜和能量色散X射线，热重分析，固态CP / MAS 13C-NMR光谱和CHNS分析。探索了制备的催化剂的效率，以合成各种1,8-二氧-八氢氧杂蒽衍生物。发现温和的反应条件与多种官能团更相容。所获得的产物可以通过简单的过滤方便地从反应混合物中分离出来，并且催化剂被回收并重新用于下一个循环而不会显着降低催化效率。该合成路线的诱人之处在于操作简便，反应时间短，转化率高，底物范围广，后处理步骤容易以及催化剂的可重复使用性。 图形摘要
• Magnetic Fe–Cr–Ni oxide alloy nano-belts prepared from the chemical decomposition of a stainless steel screw (a top-down approach): an efficient and cheap catalyst for multicomponent reactions
  作者：Milad Kazemnejadi、Zeinab Sharafi、Boshra Mahmoudi、Atefeh Zeinali、Mohammad Ali Nasseri

  DOI：10.1007/s13738-019-01814-z

  日期：2020.4

  A new, cheap, and accessible method has been used for the preparation of nano-belts from the chemical decomposition (top-down approach) of a cheap stainless steel screw and found as an efficient magnetically recyclable nanocatalyst for the preparation of quinolines and 1,8-dioxo-octahydroxanthenes under mild reaction conditions. The nano-belts, Fe–Cr–Ni oxide alloy, was prepared in a two-step synthesis and characterized with various instrumental methods. Due to magnetic property of the screw (a ferritic-alloy), the resultant nano-belts is magnetic. Magnetic Fe–Cr–Ni alloy nano-belts were applied toward efficient preparation of quinolines and 1,8-dioxo-octahydroxanthenes under mild conditions. The catalyst could be readily recovered and recycled for several consecutive runs, while it suffers from a very low metal leaching and subsequently efficiency drop.

  一种新的、廉价且易得的方法已被用于从廉价不锈钢螺丝的化学分解（自上而下的方法）中制备纳米带，并发现其在温和反应条件下作为高效的磁性可回收纳米催化剂，用于喹啉和1,8-二氧杂-八氢氧杂蒽的制备。这种纳米带，即Fe–Cr–Ni氧化物合金，是通过两步合成法制备的，并使用多种仪器方法进行了表征。由于螺丝（一种铁素体合金）的磁性特性，所得纳米带也具有磁性。磁性Fe–Cr–Ni合金纳米带在温和条件下被应用于高效制备喹啉和1,8-二氧杂-八氢氧杂蒽。该催化剂可以轻易地回收并在多次连续运行中循环使用，同时金属溶出现象极少，因此催化效率几乎不会下降。
• Green and cost effective protocol for the synthesis of 1,8-dioxo-octahydroxanthenes and 1,8-dioxo-decahydroacridines by using sawdust sulphonic acid
  作者：Shrikrishna Karhale、Monika Patil、Gajanan Rashinkar、Vasant Helavi

  DOI：10.1007/s11164-017-3059-4

  日期：2017.12

  heterogeneous solid acid catalyst has been prepared by covalent grafting of chlorosulphonic acid on the surface of sawdust (SD-OSO3H). The structure of the prepared catalyst was assessed by FT-IR, solid state CP/MAS 13C-NMR spectroscopy, field emission scanning electron microscopy and energy dispersive X-ray. The catalytic performance of the solid acid catalyst has been evaluated in the synthesis of 1,8-dio

  摘要 通过在锯末（SD-OSO 3 H）表面上共价接枝氯磺酸，制备了一种非均相固体酸催化剂。通过FT-IR，固态CP / MAS 13 C-NMR光谱，场发射扫描电子显微镜和能量色散X射线评估所制备的催化剂的结构。固体酸催化剂的催化性能已经在1，8-二氧代-八氢氧杂蒽和1，8-二氧代-十氢ac啶的合成中进行了评估。高转化率，更短的反应时间，更清洁的反应过程，对环境无害的溶剂，简单的实验和后处理程序以及催化剂的可重复使用性是我们合成路线的显着特征。 图形概要
• Catalyst-free sonochemical synthesis of 1,8-dioxo-octahydroxanthene derivatives in carboxy functionalized ionic liquid
  作者：Abhishek N. Dadhania、Vaibhav K. Patel、Dipak K. Raval

  DOI：10.1016/j.crci.2012.01.006

  日期：2012.5

  Résumé An efficient methodology for the synthesis of 1,8-dioxo-octahydroxanthene derivatives under ultrasonic irradiation at room temperature using carboxy functionalized ionic liquid 1-carboxymethyl-3-methylimidazolium tetrafluoroborate, [cmmim][BF4], without any added catalyst, is described. The reaction involves condensation between 5,5-dimethyl-1,3-cyclohexanedione (dimedone) and structurally diversed aldehydes. The resultant products were obtained in excellent isolated yield with high purity. Ionic liquid was recycled and reused with prominent retention in its activity for at least six times.

  摘要 本文描述了一种高效的方法，通过超声辐射在室温下使用羧基功能化的离子液体1-羧甲基-3-甲基咪唑鎓四氟硼酸盐[cmmim][BF4]，合成1,8-二氧o-八羟基香豆素衍生物，无需任何添加催化剂。反应涉及5,5-二甲基-1,3-环己二酮（dimedone）与结构各异的醛的缩合反应。所生成的产物在优异的分离收率和高纯度下获得。离子液体被回收再利用，活性至少保持六次。