4-氨基-N-(2-氨基乙基)苯甲酰胺 | 71160-41-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-氨基-N-(2-氨基乙基)苯甲酰胺
• 英文名称: N-(2-aminoethyl)-4-aminobenzamide
• 英文别名: 4-[(2-aminoethyl)carbamoyl]aniline；p-Amino-benzoesaeure-β-aminoethyl-amid；p-Aminobenzoesaeure-β-aminoaethylamid；4-(2-Amino-ethylcarbamoyl)-anilin；4-Amino-N-(2-aminoethyl)benzamide
• CAS: 71160-41-3
• 化学式: C₉H₁₃N₃O
• 分子量: 179.222
• InChiKey: UJJLJVJQAJWFIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  81.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-氨基-N-(2-氨基乙基)苯甲酰胺 、 moenomycin A 在 盐酸 、 sodium nitrite 、 sodium acetate 作用下， 反应 144.25h， 以4%的产率得到(5^BR)-5^B-(1-{4-[(2-aminoethyl)carbamoyl]phenyl}-3-(3-carboxypropionyl)-1H-1,2,4-triazol-5-yl)-5^B-de[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)carbamoyl]moenomycin A
  参考文献：
  名称：

  抗生素莫能霉素A与青霉素结合蛋白1b相互作用的研究。

  摘要：

  已经通过STD NMR研究了莫诺霉素衍生物与酶青霉素结合蛋白1b（PBP 1b）的相互作用。获得的结果启动了许多在A单元中修饰的莫诺霉素衍生物的合成，包括莫诺霉素-氨苄青霉素结合物及其抗生素活性的测定。描述了一种协议，该协议允许通过荧光相关光谱研究莫能霉素类似物与PBP 1b的相互作用。

  DOI：

  10.1016/s0968-0896(03)00187-1
• 作为产物：
  描述：

  N-(2-氨基乙基)-4-硝基苯甲酰胺 在 palladium on activated charcoal 环己烯 作用下， 以 乙醇 为溶剂， 反应 72.0h， 以62%的产率得到4-氨基-N-(2-氨基乙基)苯甲酰胺
  参考文献：
  名称：

  The Design of Agents To Control DNA Methylation Adducts. Enhanced Major Groove Methylation of DNA by an N-Methyl-N-nitrosourea Functionalized Phenyl Neutral Red Intercalator

  摘要：

  An N-methyl-N-nitrosourea (MNU) moiety [CH3N(N=O)C(=O)NH-] linked to the C4'-position of the 5-substituted phenyl ring of phenyl neutral red (PNR), 2-methyl-3-amino-5-[p-[[2-[(N-nitroso-N-methylcarbamoyl)amino]ethyl]carbamoyl]phenyl]-7-(dimethylamino)phenazenium chloride (MNU-PNR), has been synthesized as an approach to design a molecule that will deliver alkylating agents with some preference to guanine (Gua) in the major groove of DNA. The PNR nucleus was chosen because previous studies suggested the following: (1) PNR binds with a slight preference for G/C rich sequences; and (2) PNR intercalates into DNA from the major groove with the 5-phenyl ring pointing out into the major groove (Muller, W., Bunemann, H., and Dattagupta, N. (1975) fur. J. Biochem. 54, 279-291). It is demonstrated that MNU-PNR yields 2.6 and 6.0 times more N7-methylguanine (7-MeGua) than MNU at low salt (10 mM Tris buffer) and high salt (10 mM Tris buffer + 200 mM NaCl), respectively. It is also shown that the ratio of 7-MeGua (a major groove adduct) to N3-methyladenine (a minor groove adduct) is approximately 5 times higher for MNU-PNR than for MNU. The yield of the 7-MeGua adduct is decreased by the coaddition of a nonmethylating analogue of MNU-PNR or NaCl, but increased in the presence of the minor groove intercalator, ethidium bromide. Using a P-32-end-labeled restriction fragment, the enhanced methylation by MNU-PNR at 7-Gua is confirmed, and it is demonstrated that the sequence-dependent formation of 7-MeGua from MNU-PNR is the same as that seen with MNU. UV, circular dichroism, and viscosity studies are consistent with MNU-PNR binding to DNA via an intercalation-based process.

  DOI：

  10.1021/tx960007n

文献信息

• A Method for the Selective Protection of Aromatic Amines in the Presence of Aliphatic Amines
  作者：Boulos Zacharie、Valérie Perron、Shaun Abbott、Nancie Moreau、Devin Lee、Christopher Penney

  DOI：10.1055/s-0028-1083290

  日期：2009.1

  aromatic amines in the presence of aliphatic amines. The method is general for the preparation of mono-N-Boc, -N-Cbz, -N-Fmoc or -N-Alloc aromatic amines in high yield without affecting the aliphatic amines. This approach is applicable to substituted (aminoalkyl)aniline compounds with different functionalities and was employed to supply gram quantities of the protected aniline product. amines - carbamates

  已经开发了一种简单有效的方法，用于在脂肪胺存在下对芳香胺进行区域选择性保护。该方法是一般为单-的制备Ñ -Boc， - Ñ -Cbz， - ñ -Fmoc或- ñ以高收率-alloc芳香胺而不影响脂族胺。该方法适用于具有不同官能度的取代的（氨基烷基）苯胺化合物，并用于提供克量的受保护的苯胺产品。 胺-氨基甲酸酯-保护基-质子化-区域选择性
• Cosmetic process for attenuating wrinkles
  申请人：L'OREAL

  公开号：US10328014B2

  公开（公告）日：2019-06-25

  The invention relates to a cosmetic process for caring for the skin, more particularly facial skin, in particular wrinkled skin, comprising the topical application to the skin of a cosmetic composition comprising a grafted polysaccharide polymer (I) and exposure of the treated skin to light radiation, polymer (I) being of formula: PS—(CO—NH-L-X)a(COOH)b in which PS denotes the basic backbone of the polysaccharide bearing the carboxylic acid groups; L is a divalent hydrocarbon-based group containing from 1 to 20 carbon atoms; X denotes a photoactive group of azide or diazirine type; a denotes the content of COOH groups substituted with the group —NH-L-X; b denotes the content of unsubstituted free COOH groups; a being between 0.01 and 0.8; b being between 0.2 and 0.99; a+b=1 The invention also relates to the polymers (I) bearing a photoactive group X of diazirine type and to a composition comprising such a polymer in a physiologically acceptable medium.

  本发明涉及一种用于护理皮肤，特别是面部皮肤，尤其是皱纹皮肤的化妆品工艺，包括在皮肤上局部涂抹由接枝多糖聚合物（I）组成的化妆品组合物，并将处理过的皮肤置于光辐射下，聚合物（I）的化学式为 PS-(CO-NH-L-X)a(COOH)b 其中 PS 表示带有羧酸基团的多糖基本骨架； L 是含有 1 至 20 个碳原子的二价烃基； X 表示叠氮或重氮啶类的光活性基团； a 表示被基团-NH-L-X 取代的 COOH 基团的含量； b 表示未取代的游离 COOH 基团的含量； a 介于 0.01 和 0.8 之间；b 介于 0.2 和 0.99 之间； a+b=1 本发明还涉及带有重氮氨酸型光活性基团 X 的聚合物 (I)，以及在生理上可接受的介质中包含这种聚合物的组合物。
• COSMETIC PROCESS FOR ATTENUATING WRINKLES
  申请人：L'OREAL

  公开号：EP3233041B1

  公开（公告）日：2019-01-30
• US4072664A
  申请人：——

  公开号：US4072664A

  公开（公告）日：1978-02-07
• Studies on the interaction of the antibiotic moenomycin A with the enzyme penicillin-binding protein 1b
  作者：Thomas Rühl、Mohammed Daghish、Andrij Buchynskyy、Karen Barche、Daniela Volke、Katherina Stembera、Uwe Kempin、Dietmar Knoll、Lothar Hennig、Matthias Findeisen、Ramona Oehme、Sabine Giesa、Juan Ayala、Peter Welzel

  DOI：10.1016/s0968-0896(03)00187-1

  日期：2003.7

  enzyme penicillin binding protein 1b (PBP 1b) has been studied by means of STD NMR. The results obtained initiated the synthesis of a number of moenomycin derivatives modified in unit A including a moenomycin-ampicillin conjugate and determination of their antibiotic activities. A protocol is described that allows studying the interaction of moenomycin analogues with PBP 1b by fluorescence correlation

  已经通过STD NMR研究了莫诺霉素衍生物与酶青霉素结合蛋白1b（PBP 1b）的相互作用。获得的结果启动了许多在A单元中修饰的莫诺霉素衍生物的合成，包括莫诺霉素-氨苄青霉素结合物及其抗生素活性的测定。描述了一种协议，该协议允许通过荧光相关光谱研究莫能霉素类似物与PBP 1b的相互作用。