2,6-dichloro-4-(nitrophenyl)-N¹,N¹-dimethylformamidine | 2350-60-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-dichloro-4-(nitrophenyl)-N¹,N¹-dimethylformamidine
• 英文别名: N'-(2,6-dichloro-4-nitrophenyl)-N,N-dimethylformamidine；N'-(2,6-dichloro-4-nitrophenyl)-N,N-dimethylmethanimidamide
• CAS: 2350-60-9
• 化学式: C₉H₉Cl₂N₃O₂
• mdl: MFCD22055698
• 分子量: 262.095
• InChiKey: GIIFEBWDJXMMJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  61.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,6-dichloro-4-(nitrophenyl)-N¹,N¹-dimethylformamidine 在 盐酸 、 tin(ll) chloride 作用下， 反应 18.0h， 以84%的产率得到N²-(4-amino-2,6-dichlorophenyl)-N¹,N¹-dimethylformamidine
  参考文献：
  名称：

  N2-(4-Substituted-2,6-dichlorophenyl)-N1,N1-dimethylformamidines as antihypertensive and diuretic agents

  摘要：

  The synthesis of a series of N2-[4-[(arylmethyl)amino]-2, 6-dichlorophenyl]-N1,N1-dimethylformamidines that caused marked blood pressure lowering and/or diuresis in spontaneously hypertensive rats (SHR) is reported. Diuretic activity was not always associated with acute antihypertensive activity. Central nervous system effects, most notably sedation, were observed. Compound 9d, which lowered arterial blood pressure 37 mmHg in SHR when dosed at 100 mg/kg, was further evaluated in chronic hypertensive dogs because of apparent minimal CNS effects. A reduction in arterial blood pressure of 32 mmHg at 1.0 mg/kg during a 6-h postdosing interval was observed. This response was unrelated to alpha- or beta-adrenergic blockade, angiotensin I antagonism, or neuronal or ganglionic blockade. CNS effects were also observed.

  DOI：

  10.1021/jm00378a030
• 作为产物：
  描述：

  2,6-Dichloro-4-nitrophenyl isocyanide 在 氯化亚砜 、 水 、 三氟乙酸 作用下， 以 氯仿 为溶剂， 生成 2,6-dichloro-4-(nitrophenyl)-N¹,N¹-dimethylformamidine
  参考文献：
  名称：

  Mironov; Mokrushin, Russian Journal of Organic Chemistry, 1999, vol. 35, # 5, p. 693 - 697

  摘要：

  DOI：

文献信息

• N'-(2,
  申请人：American Cyanamid Company

  公开号：US04368335A1

  公开（公告）日：1983-01-11

  This disclosure describes novel N'-[2,6-dichloro-4-(substituted-benzylamino)phenyl]-N,N-dimethyl-formamidi nes which possess activity as hypotensive agents and as diuretics.

  本披露描述了一种新型的N'-[2,6-二氯-4-(取代苯基氨基)苯基]-N,N-二甲基甲酰胺，具有作为降压剂和利尿剂的活性。
• Unusually versatile Vilsmeier-Haack reagents
  作者：F.L. Scott、J.A. Barry

  DOI：10.1016/s0040-4039(00)76155-7

  日期：1968.1
• Mironov; Mokrushin, Russian Journal of Organic Chemistry, 1999, vol. 35, # 5, p. 693 - 697
  作者：Mironov、Mokrushin

  DOI：——

  日期：——
• N2-(4-Substituted-2,6-dichlorophenyl)-N1,N1-dimethylformamidines as antihypertensive and diuretic agents
  作者：Walter E. Meyer、Andrew S. Tomcufcik、Peter S. Chan、John E. Emma

  DOI：10.1021/jm00378a030

  日期：1984.12

  The synthesis of a series of N2-[4-[(arylmethyl)amino]-2, 6-dichlorophenyl]-N1,N1-dimethylformamidines that caused marked blood pressure lowering and/or diuresis in spontaneously hypertensive rats (SHR) is reported. Diuretic activity was not always associated with acute antihypertensive activity. Central nervous system effects, most notably sedation, were observed. Compound 9d, which lowered arterial blood pressure 37 mmHg in SHR when dosed at 100 mg/kg, was further evaluated in chronic hypertensive dogs because of apparent minimal CNS effects. A reduction in arterial blood pressure of 32 mmHg at 1.0 mg/kg during a 6-h postdosing interval was observed. This response was unrelated to alpha- or beta-adrenergic blockade, angiotensin I antagonism, or neuronal or ganglionic blockade. CNS effects were also observed.