(R)-2,2-Dimethyl-4-((Z)-4-phenyl-but-1-enyl)-thiazolidine-3-carboxylic acid tert-butyl ester | 198764-24-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-2,2-Dimethyl-4-((Z)-4-phenyl-but-1-enyl)-thiazolidine-3-carboxylic acid tert-butyl ester
• CAS: 198764-24-8
• 化学式: C₂₀H₂₉NO₂S
• 分子量: 347.522
• InChiKey: SIQLCPMVOBIFOU-OOXMNIKJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.26
• 重原子数：
  24.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  29.54
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (R)-2,2-Dimethyl-4-((Z)-4-phenyl-but-1-enyl)-thiazolidine-3-carboxylic acid tert-butyl ester 在 双(2-氧代-3-恶唑烷基)次磷酰氯 、 三乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 (1R,2S)-2-Methyl-cyclopropanecarbothioic acid S-((Z)-(R)-2-tert-butoxycarbonylamino-6-phenyl-hex-3-enyl) ester
  参考文献：
  名称：

  Design and synthesis of curacin a analogs with varied side chain structures

  摘要：

  A series of side chain-modified analogs of curacin A, a powerful antimitotic agent isolated from a Caribbean cyanobacterium was synthesized and the effect of these compounds on in vitro microtubule polymerization was examined. The analogs showed weak or no anti-tubulin activity, suggesting that the whole side chain structure of curacin A is required for the interaction with tubulin. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)10055-5
• 作为产物：
  描述：

  tert-butyl (4R)-4-[methoxy(methyl)carbamoyl]-2,2-dimethyl-1,3-thiazolidine-3-carboxylate 在 lithium aluminium tetrahydride 、 sodium hexamethyldisilazane 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 生成 (R)-2,2-Dimethyl-4-((Z)-4-phenyl-but-1-enyl)-thiazolidine-3-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  Design and synthesis of curacin a analogs with varied side chain structures

  摘要：

  A series of side chain-modified analogs of curacin A, a powerful antimitotic agent isolated from a Caribbean cyanobacterium was synthesized and the effect of these compounds on in vitro microtubule polymerization was examined. The analogs showed weak or no anti-tubulin activity, suggesting that the whole side chain structure of curacin A is required for the interaction with tubulin. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)10055-5