1-phenyl acetyl-azatedin-2-one | 405219-59-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 1-phenyl acetyl-azatedin-2-one
• 英文别名: 1-(2-Phenylacetyl)azetidin-2-one
• CAS: 405219-59-2
• 化学式: C₁₁H₁₁NO₂
• 分子量: 189.214
• InChiKey: VEZHKXQYJUMRRV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氮杂环丁酮 、 苯乙醛 在 Shvo's Catalyst 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以55%的产率得到1-phenyl acetyl-azatedin-2-one
  参考文献：
  名称：

  Direct N-Acylation of Lactams, Oxazolidinones, and Imidazolidinones with Aldehydes by Shvo’s Catalyst

  摘要：

  Direct N-acylation of lactams, oxazolidinones, and imidazolidinones was achieved with aldehydes by Shvo's catalyst without using any other stoichiometric reagent. The N-acylations with alpha,beta-unsaturated aldehydes were achieved with excellent yields.

  DOI：

  10.1021/ol302087z

文献信息

• EP1318806A4
  申请人：——

  公开号：EP1318806A4

  公开（公告）日：2004-01-21
• FATTY ACID SYNTHASE INHIBITORS
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1318806A1

  公开（公告）日：2003-06-18
• [EN] FATTY ACID SYNTHASE INHIBITORS<br/>[FR] INHIBITEURS DES SYNTASES D'ACIDES GRAS
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2002024197A1

  公开（公告）日：2002-03-28

  This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.
• Direct <i>N</i>-Acylation of Lactams, Oxazolidinones, and Imidazolidinones with Aldehydes by Shvo’s Catalyst
  作者：Jian Zhang、Soon Hyeok Hong

  DOI：10.1021/ol302087z

  日期：2012.9.7

  Direct N-acylation of lactams, oxazolidinones, and imidazolidinones was achieved with aldehydes by Shvo's catalyst without using any other stoichiometric reagent. The N-acylations with alpha,beta-unsaturated aldehydes were achieved with excellent yields.