2,6-dichloro-4-(6-(4-chlorophenethoxy)-5-(4-(3-methoxy-4-(2-(4-methylpiperazin-1-yl)ethoxy)benzyl)piperazin-1-yl)pyridazin-3-yl)phenol | 1251769-37-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2,6-dichloro-4-(6-(4-chlorophenethoxy)-5-(4-(3-methoxy-4-(2-(4-methylpiperazin-1-yl)ethoxy)benzyl)piperazin-1-yl)pyridazin-3-yl)phenol
• 英文别名: 2,6-Dichloro-4-[6-[2-(4-chlorophenyl)ethoxy]-5-[4-[[3-methoxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]methyl]piperazin-1-yl]pyridazin-3-yl]phenol
• CAS: 1251769-37-5
• 化学式: C₃₇H₄₃Cl₃N₆O₄
• 分子量: 742.145
• InChiKey: LTUFFXKPCRJGRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  50
• 可旋转键数：
  13
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  86.7
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• Compounds, Compositions and Methods Comprising Pyridazine Derivatives
  申请人：Russell Michael Geoffrey Neil

  公开号：US20100267706A1

  公开（公告）日：2010-10-21

  The present invention relates to compounds, compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1 or 2 or encompassed by formulas I, Ia, II, III, and IV) or compositions comprising these compounds, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

  本发明涉及化合物、组合物和方法，用于治疗动物中对抑制功能性囊性纤维化跨膜传导调节因子（CFTR）多肽敏感的疾病，通过向需要的哺乳动物中给予本文中定义的化合物的有效量（包括表1或2中列出的化合物或由公式I、Ia、II、III和IV包含的化合物）或包含这些化合物的组合物，从而治疗该疾病。本发明特别涉及一种治疗腹泻和多囊肾病的方法。