5-(2-methoxy-ethyl)-pyrimidine-2,4,6-trione | 25651-45-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-(2-methoxy-ethyl)-pyrimidine-2,4,6-trione
• 英文别名: 5-(2-Methoxyethyl)-1,3-diazinane-2,4,6-trione
• CAS: 25651-45-0
• 化学式: C₇H₁₀N₂O₄
• 分子量: 186.167
• InChiKey: MGUHHBFBSZFSAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  84.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors
  申请人：——

  公开号：US20040006057A1

  公开（公告）日：2004-01-08

  The present invention relates to triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione; metalloproteinase inhibitors of the formula 1 wherein X, A, Y, B, G, W, and R 1 are as defined in the specification, and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.

  本发明涉及三芳基氧基吡啶二酮类金属蛋白酶抑制剂，其化学式为1，其中X、A、Y、B、G、W和R1如规范中所定义，并涉及用于治疗炎症、癌症和其他疾病的药物组合物和方法。
• TRIARYL-OXY-ARYLOXY-PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS
  申请人：Pfizer Products Inc.

  公开号：EP1501515B1

  公开（公告）日：2005-11-02
• US7119201B2
  申请人：——

  公开号：US7119201B2

  公开（公告）日：2006-10-10
• [EN] TRIARYL-OXY-ARYLOXY-PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS<br/>[FR] INHIBITEURS DE METALLOPROTEINASE TRIARYL-OXY-ARYLOXY-PYRIMIDINE-2,4,6-TRIONE
  申请人：PFIZER PROD INC

  公开号：WO2003090752A1

  公开（公告）日：2003-11-06

  The present invention relates to triaryl-oxy-aryloxy-pyrimidine-2,4.6-trione; metalloproteinase inhibitors of the formula wherein X, A, Y, B, G, W. and R1 are as defined in the specification, and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.