cis-[Pt(3,5-lutidine)2I2] | 36515-79-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: cis-[Pt(3,5-lutidine)2I2]
• 英文别名: cis-{Pt(3,5-diMe-py)2I2}；cis-[PtI2(3,5-lutidine)2]；cis-Pt(3,5-lutidine)2I2；trans-{Pt(3,5-diMe-py)2I2}；trans-[Pt(3,5-lutidine)2I2]
• CAS: 36515-79-4；128385-92-2
• 化学式: C₁₄H₁₈I₂N₂Pt
• 分子量: 663.199
• InChiKey: CYUXRYYTBUZDJP-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  cis-[Pt(3,5-lutidine)2I2] 、 二甲基亚砜 以 neat (no solvent) 为溶剂， 以62%的产率得到trans-{(dimethyl sulphoxide)diiodo(3,5-dimethylpyridine)}platinum(II)
  参考文献：
  名称：

  Ha, Tam T. B.; Wimmer, Franz L.; Souchard, Jean-Pierre, Journal of the Chemical Society, Dalton Transactions

  摘要：

  DOI：
• 作为产物：
  描述：

  3,5-二甲基吡啶 、 potassium tetrachloroplatinate(II) 在 KI 作用下， 以 水 为溶剂， 以91%的产率得到cis-[Pt(3,5-lutidine)2I2]
  参考文献：
  名称：

  Ha, Tam T. B.; Wimmer, Franz L.; Souchard, Jean-Pierre, Journal of the Chemical Society, Dalton Transactions

  摘要：

  DOI：

文献信息

• Synthesis, IR and multinuclear NMR spectroscopies and crystallographic studies of complexes of the type cis- and trans-Pt(pyridine)2(NO3)2
  作者：Christian Tessier、Fernande D. Rochon

  DOI：10.1016/s0020-1693(01)00550-3

  日期：2001.10

  at lower fields than the others. The coupling constants 3J(195Pt–1H) and 3J(195Pt–13C) are larger in the cis configuration (ave. 44 and 46 Hz, respectively) than in the trans analogs (ave. 33 and 35 Hz, respectively). The covalent character of the PtO bond seems greater in the trans complexes than in the cis compounds. The crystal structures of cis-Pt(3,5-lut)2(NO3)2, cis-Pt(2-pic)2(NO3)2, cis-Pt(py)2(NO3)2·1/2CH2Cl2

  合成了顺式和反式Pt（Ypy）2（NO 3）2（Ypy =吡啶或其甲基衍生物）类型的化合物，并通过IR和多核（195 Pt，13 C和1 H）NMR光谱进行了表征。在比顺式类似物（平均-1509 ppm）更低的场（平均-1450 ppm）下观察到反式配合物的195 Pt NMR共振。在比其他低的电场下观察到在吡啶配体上邻位含有甲基取代基的配合物。耦合常数3 J（顺式构型（分别为44 Hz和46 Hz）中的195 Pt– 1 H）和3 J（195 Pt– 13 C）大于反式类似物（分别为Ave 33和35 Hz）中的值。在反式配合物中，Pt = O键的共价特征似乎比顺式化合物更大。的晶体结构的顺式-Pt（3,5- LUT）2（NO 3）2，顺式-Pt（2-PIC）2（NO 3）2，顺式-Pt（PY）2（NO3）2 ·1 / 2CH 2 Cl 2，反式-Pt（3,5-lut）2（NO 3）2和反式-Pt（py）2（NO
• Multinuclear magnetic resonance studies of the aqueous products of the complexes <i>cis</i>- and <i>trans</i>-Pt(Ypy)₂(NO₃)₂ where Ypy = pyridine derivative
  作者：Fernande D Rochon、Christian Tessier

  DOI：10.1139/v02-043

  日期：2002.4.1

  The hydrolyis or the aquation reactions of compounds of the types cis- and trans-Pt(Ypy)₂(NO₃)₂ (Ypy = pyridine derivative) were studied in D₂O and characterized by multinuclear (¹⁹⁵Pt, ¹³C, and ¹H) NMR spectroscopy. In acidic pD, the product of the cis complexes is cis-[Pt(Ypy)₂(D₂O)₂]²⁺, whereas in basic medium cis-Pt(Ypy)₂(OD)₂ is formed. The ¹⁹⁵Pt NMR resonances of the products containing ligands with an ortho substituent were observed at lower fields than the other complexes. The average coupling constant (³J(¹⁹⁵Pt–¹H) and ³J(¹⁹⁵Pt–¹³C)) is 44 Hz for the diaqua species and 42 Hz for the dihydroxo compounds. At neutral pD, several hydrolyzed species were observed, except for the 2-picoline and 2,4-lutidine complexes, which contained only one compound, cis-[Pt(Ypy)₂(D₂O)(OD)]⁺. The other hydrolyzed products for the ligands with no ortho substituent were identified as the dihydroxo-bridged dimer, the monohydroxo-bridged dimer, the trimer, and possibly the tetramer. The trans analogues have shown two signals in acidic pD corresponding to the diaqua monomer and the monohydroxo-bridged aqua dimer. Two species (the dihydroxo compound and the monohydroxo-bridged hydroxo dimer) were also observed in basic pD. In neutral medium, a third signal assigned to a longer chain hydroxo-bridged oligomer or polymer was detected.Key words: platinum, pyridine derivative, nitrato, hydrolysis, NMR, aquation.

  研究了cis-和trans-Pt（Ypy）2（NO3）2（Ypy =吡啶衍生物）化合物的水解或水合反应，并通过多核（195Pt，13C和1H）NMR光谱表征。在酸性pD条件下，cis配合物的产物是cis-[Pt（Ypy）2（D2O）2]2+，而在碱性介质中形成cis-Pt（Ypy）2（OD）2。含有邻位取代基的配体的产物的195Pt NMR共振峰位于低场，而其他配合物则位于高场。双水合物种的平均耦合常数（3J（195Pt-1H）和3J（195Pt-13C））为44 Hz，双羟基化合物的平均耦合常数为42 Hz。在中性pD下，观察到几种水解产物，除了2-哌啶和2,4-二甲基吡啶配合物仅含有一种化合物cis-[Pt（Ypy）2（D2O）（OD）]+。其他无邻位取代基的配体的水解产物被鉴定为双羟基桥联二聚体，单羟基桥联二聚体，三聚体和可能的四聚体。在酸性pD条件下，trans类似物显示出两个信号，对应于双水合物单体和单羟基桥联水二聚体。在碱性pD条件下，也观察到两种物种（双羟基化合物和单羟基桥联羟基二聚体）。在中性介质中，检测到被指定为较长链羟基桥联寡聚物或聚合物的第三个信号。关键词：铂，吡啶衍生物，硝酸盐，水解，NMR，水合。
• Biological evaluation of dimethylpyridine–platinum complexes with potent antiproliferative activity
  作者：Robert Czarnomysy、Krzysztof Bielawski、Anna Muszynska、Anna Bielawska、Agnieszka Gornowicz

  DOI：10.1080/14756366.2016.1212191

  日期：2016.11.3

  This study investigates the effect of three new platinum complexes: Pt2(2,4-dimethylpyridine)4(berenil)2 (Pt14), Pt2(3,4-dimethylpyridine)4(berenil)2 (Pt15) and Pt2(3,5-dimethylpyridine)4(berenil)2 (Pt16) on growth and viability of breast cancer cells and their putative mechanism(s) of cytotoxicity. Cytotoxicity was measured with MTT assay and inhibition of [3H]thymidine incorporation into DNA in both breast cancer cells. Results revealed that Pt14-Pt16 exhibit substantially greater cytotoxicity than cisplatin against MCF-7 and MDA-MB-231 breast cancer cells. In the case of human skin fibroblast cell, cytotoxicity assays demonstrated that these compounds are less toxic to normal cells than cisplatin. In addition, the effects of Pt14-Pt16 are investigated using the flow cytometry assessment of annexin V binding, analysis of mitochondrial potential, markers of apoptosis such as caspase-3, caspase-8, caspase-9, caspase-10 and defragmentation of DNA by TUNEL assay. These results indicate that Pt14-Pt16 induce apoptosis by the mitochondrial and external pathway.