| 1442657-28-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1442657-28-4
• 化学式: C₄₂H₅₉N₄O₄P
• 分子量: 714.929
• InChiKey: KEAFAXHGURMCTB-MGXDLYCJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  51.0
• 可旋转键数：
  11.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  100.72
• 氢给体数：
  4.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以96%的产率得到
  参考文献：
  名称：

  Novel chiral C2-symmetric multidentate aminophosphine ligands for use in catalytic asymmetric reduction of ketones

  摘要：

  A series of novel chiral C-2-symmetric multidentate aminophosphine ligands have been successfully synthesized by Schiff-base condensation of bis(o-formylphenyl)phenylphosphane and easily available monoprotected (1R,2R)-diaminocyclohexane. The catalytic properties of these ligands were investigated in Ir-catalyzed asymmetric transfer hydrogenation of various aromatic ketones, giving the corresponding optical active alcohols with up to 98% conversion and good ee under mild reaction conditions. (C) 2013 Yan-Yun Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.03.043
• 作为产物：
  描述：

  (1R,2R)-反式-N-Boc-1,2-二氨基环己烷 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 46.0h， 生成
  参考文献：
  名称：

  Novel chiral C2-symmetric multidentate aminophosphine ligands for use in catalytic asymmetric reduction of ketones

  摘要：

  A series of novel chiral C-2-symmetric multidentate aminophosphine ligands have been successfully synthesized by Schiff-base condensation of bis(o-formylphenyl)phenylphosphane and easily available monoprotected (1R,2R)-diaminocyclohexane. The catalytic properties of these ligands were investigated in Ir-catalyzed asymmetric transfer hydrogenation of various aromatic ketones, giving the corresponding optical active alcohols with up to 98% conversion and good ee under mild reaction conditions. (C) 2013 Yan-Yun Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.03.043