2-pyrrolidin-2-ylbenzimidazole-4-carboxamide | 1109218-99-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-pyrrolidin-2-ylbenzimidazole-4-carboxamide
• 英文别名: 2-pyrrolidin-2-yl-1H-benzimidazole-4-carboxamide
• CAS: 1109218-99-6
• 化学式: C₁₂H₁₄N₄O
• 分子量: 230.269
• InChiKey: HTZYXVMVVCKCTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  83.8
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] MITOCHONDRIALLY TARGETED PARP INHIBITOR, AND USES THEREOF<br/>[FR] INHIBITEUR DE PARP À CIBLAGE MITOCHONDRIAL, ET SES UTILISATIONS
  申请人：UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION

  公开号：WO2018071761A1

  公开（公告）日：2018-04-19

  A mitochondrial-targeted PARP inhibitor is provided herein, as well as methods of making and using the mitochondrial-targeted PARP inhibitor.

  本文提供了一种定位于线粒体的PARP抑制剂，以及制备和使用该线粒体定位的PARP抑制剂的方法。
• Heterocyclic degronimers for target protein degradation
  申请人：C4 Therapeutics, Inc.

  公开号：US10905768B1

  公开（公告）日：2021-02-02

  This invention provides heterocyclic compounds that bind to E3 Ubiquitin Ligase (typically through cereblon) (“Degrons”), which can be used as is or linked to a Targeting Ligand for a selected Target Protein for therapeutic purposes and methods of use and compositions thereof as well as methods for their preparation.

  本发明提供了能与 E3 泛素连接酶（通常是通过脑龙）（"Degrons"）结合的杂环化合物，这些杂环化合物可用于治疗目的或与选定靶蛋白的靶向配体相连接，并提供了其使用方法和组合物及其制备方法。
• Spirocyclic degronimers for target protein degradation
  申请人：C4 Therapeutics, Inc.

  公开号：US11185592B2

  公开（公告）日：2021-11-30

  This invention provides compounds that have spirocyclic E3 Ubiquitin Ligase targeting moieties (Degrons), which can be used as is or linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.

  本发明提供了具有螺环 E3 泛素连接酶靶向基团（Degrons）的化合物，这些化合物可单独使用，也可与用于体内降解的蛋白质的靶向配体连接，本发明还提供了其使用方法和组合物及其制备方法。
• HETEROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION
  申请人：C4 Therapeutics, Inc.

  公开号：US20190076541A1

  公开（公告）日：2019-03-14

  This invention provides heterocyclic compounds that bind to E3 Ubiquitin Ligase (typically through cereblon) (“Degrons”), which can be used as is or linked to a Targeting Ligand for a selected Target Protein for therapeutic purposes and methods of use and compositions thereof as well as methods for their preparation.
• SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION
  申请人：C4 Therapeutics, Inc.

  公开号：US20210106688A1

  公开（公告）日：2021-04-15

  This invention provides compounds that have spirocyclic E3 Ubiquitin Ligase targeting moieties (Degrons), which can be used as is or linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.