1-methyl-azepane-2,3-dione | 52774-43-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 1-methyl-azepane-2,3-dione
• 英文别名: 1-Methyl-2,3-dioxo-hexahydro-azepin；1-Methyl-2,3-dioxo-hexahydroazepin；1-Methyl-2,3-dioxohexahydroazepine；1-methylazepane-2,3-dione
• CAS: 52774-43-3
• 化学式: C₇H₁₁NO₂
• 分子量: 141.17
• InChiKey: SMSLSBSOFJKZOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-methyl-azepane-2,3-dione 、 氨基硫脲 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成 [(1-methyl-2-oxoazepan-3-ylidene)amino]thiourea
  参考文献：
  名称：

  Edelstein; Avramoff; Shtacher, European Journal of Medicinal Chemistry, 1980, vol. 15, # 6, p. 566 - 566

  摘要：

  DOI：

文献信息

• [EN] CYCLIC KETO-AMIDE COMPOUNDS AS CALPAIN MODULATORS AND METHODS OF PRODUCTION AND USE THEREOF<br/>[FR] COMPOSÉS CÉTO-AMIDES CYCLIQUES UTILISÉS EN TANT QUE MODULATEURS DE LA CALPAÏNE, ET LEURS PROCÉDÉS DE PRODUCTION ET D'UTILISATION
  申请人：BLADE THERAPEUTICS INC

  公开号：WO2017156071A1

  公开（公告）日：2017-09-14

  The present technology relates to cyclic keto-amide compounds of general formulae I to XXXII, compositions and kits thereof as calpain modulators and methods useful for the treatment of various diseases or disorders such as fibrotic disease or cancer which are associated or mediated, by calpains, such as CAPN1, CAPN2, and/or CAPN9. The present technology is also applicable to cyclic keto-amide compounds which inhibit myofibroblast differentiation.

  目前的技术涉及一般式I至XXXII的环状酮酰胺化合物，以及作为钙蛋白酶调节剂的组合物和试剂盒，以及用于治疗与钙蛋白酶（如CAPN1、CAPN2和/或CAPN9）相关或介导的各种疾病或紊乱的方法，如纤维化疾病或癌症。目前的技术还适用于抑制肌成纤维细胞分化的环状酮酰胺化合物。
• Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof
  申请人：Blade Therapeutics, Inc.

  公开号：US10590084B2

  公开（公告）日：2020-03-17

  The present technology relates to cyclic keto-amide compounds of general formulae I to XXXII, compositions and kits thereof as calpain modulators and methods useful for the treatment of various diseases or disorders such as fibrotic disease or cancer which are associated or mediated, by calpains, such as CAPN1, CAPN2, and/or CAPN9. The present technology is also applicable to cyclic keto-amide compounds which inhibit myofibroblast differentiation.

  本技术涉及通式I至XXXII的环酮酰胺化合物、其作为钙蛋白酶调节剂的组合物和试剂盒，以及用于治疗与钙蛋白酶（如CAPN1、CAPN2和/或CAPN9）相关或由其介导的各种疾病或紊乱（如纤维化疾病或癌症）的方法。本技术也适用于抑制肌成纤维细胞分化的环酮酰胺化合物。
• EDELSTEIN F.; AVRAMOFF M.; SHTACHER G.; TEITZ Y., EUR. J. MED. CHEM.-CHIM. THER., 1980, 15, NO 6, 566
  作者：EDELSTEIN F.、 AVRAMOFF M.、 SHTACHER G.、 TEITZ Y.

  DOI：——

  日期：——
• CYCLIC KETO-AMIDE COMPOUNDS AS CALPAIN MODULATORS AND METHODS OF PRODUCTION AND USE THEREOF
  申请人：Blade Therapeutics, Inc.

  公开号：US20190194139A1

  公开（公告）日：2019-06-27

  The present technology relates to cyclic keto-amide compounds of general formulae I to XXXII, compositions and kits thereof as calpain modulators and methods useful for the treatment of various diseases or disorders such as fibrotic disease or cancer which are associated or mediated, by calpains, such as CAPN1, CAPN2, and/or CAPN9. The present technology is also applicable to cyclic keto-amide compounds which inhibit myofibroblast differentiation.
• Edelstein; Avramoff; Shtacher, European Journal of Medicinal Chemistry, 1980, vol. 15, # 6, p. 566 - 566
  作者：Edelstein、Avramoff、Shtacher、Teitz

  DOI：——

  日期：——