5-(3-chloropropylamino)-2-methyl-2H-pyridazine-3-one hydrochloride | 619309-16-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-(3-chloropropylamino)-2-methyl-2H-pyridazine-3-one hydrochloride
• 英文别名: 5-(3-Chloropropylamino)-2-methyl-2h-pyridazine-3-one-hydrochloride；5-(3-chloropropylamino)-2-methylpyridazin-3-one;hydrochloride
• CAS: 619309-16-9
• 化学式: C₈H₁₂ClN₃O*ClH
• 分子量: 238.117
• InChiKey: YMBSEQCUTARKOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.24
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  44.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-(3-chloropropylamino)-2-methyl-2H-pyridazine-3-one hydrochloride 、 6-氟-3-(哌啶-4-基)苯并[D]异恶唑 在 potassium carbonate 、 potassium iodide 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以62.2%的产率得到5-{3-[4-(6-fluoro-1,2-benzisoxazole-3-yl)-piperidine-1-yl]-propylamino}-2-methyl-2H-pyridazine-3-one
  参考文献：
  名称：

  [EN] NEW PIPERIDINYL-ALKYLAMINO-PYRIDAZINONE DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS
  [FR] NOUVEAUX DERIVES DE PIPERIDINYL-ALKYLAMINO-PYRIDAZINONE, PROCEDE DE PREPARATION DE CEUX-CI ET COMPOSITIONS PHARMACEUTIQUES CONTENANT CES COMPOSES

  摘要：

  本发明涉及一种新的吡哆啉基-烷基氨基-吡啶嗪酮衍生物，其一般式为（I）（其中R为氢或C1-4-烷基；X和Y中的一个代表氢，另一个代表一般式（II）的基团，Hal代表卤素；n为1或2），以及其药学上可接受的酸加成盐的制备方法和包含所述化合物的制剂。一般式I的化合物具有抗焦虑作用，可用于治疗焦虑症。

  公开号：

  WO2003091244A1

文献信息

• Piperidinyl-alkylamino-pyridazinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing said compounds
  申请人：Barkoczy Jozsef

  公开号：US20050215560A1

  公开（公告）日：2005-09-29

  The invention relates to new piperidinyl-alkylamino-pyridazinone derivatives of the general Formula (I) (wherein R is hydrogen or C 1-4 -alkyl; one of X and Y stands for hydrogen and the other represents a group of the general Formula (II) Hal stands for halogen; and n is 1 or 2) and pharmaceutically acceptable acid addition salts thereof a process for the preparation thereof and pharmaceutical compositions comprising said compounds. The compounds of the general Formula I exhibit anxiolytic effect and are useful in the treatment of anxiety.

  本发明涉及新的哌啶基-烷基氨基-吡啶嗪酮衍生物，其一般式为(I)，其中R为氢或C1-4-烷基；X和Y中的一个表示氢，另一个表示一般式(II)的基团，Hal表示卤素；n为1或2。还涉及其药学上可接受的酸盐制备方法和含有该化合物的药物组合物。一般式I的化合物表现出抗焦虑作用，可用于焦虑症的治疗。
• NOVEL 2H-PYRIDAZINE-3-ONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND A PROCESS FOR THE PREPARATION OF THE ACTIVE INGREDIENT
  申请人：EGIS Gyógyszergyár Nyrt

  公开号：EP1417206B1

  公开（公告）日：2010-05-05
• NEW PIPERIDINYL-ALKYLAMINO-PYRIDAZINONE DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS
  申请人：EGIS GYOGYSZERGYAR RT.

  公开号：EP1501823A1

  公开（公告）日：2005-02-02
• Novel 2h-pyridazine-3-one derivatives, pharmaceutical compositions containing the same and a process for the preparation of the active ingredient
  申请人：——

  公开号：US20040171619A1

  公开（公告）日：2004-09-02

  The invention refers to novel 2H-pyridazine-3-one derivatives of the formula I, pharmaceutical compositions containing the same and a process for the preparation of the active ingredient. The novel compounds possess neuroleptic effect and can be used, primarily, for the treatment of schizophrenia. In formula I, R stands for a hydrogen atom or a C 1-4 , alkyl group, X and Y represent, independently, a hydrogen atom, a halogen atom or a group of the formula II, with the proviso that one of X and Y means always a group of the formula II, and then the other one stands for a hydrogen atom or a halogen atom, wherein in formula II n has a value of 1 or 2. 1
• US7098210B2
  申请人：——

  公开号：US7098210B2

  公开（公告）日：2006-08-29