3-((2,5-dimethoxyphenyl)ethynyl)thiophene | 1073188-68-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-((2,5-dimethoxyphenyl)ethynyl)thiophene
• 英文别名: 1-(2,5-dimethoxyphenyl)-2-(thien-3-yl)ethyne；3-[2-(2,5-Dimethoxyphenyl)ethynyl]thiophene
• CAS: 1073188-68-7
• 化学式: C₁₄H₁₂O₂S
• 分子量: 244.314
• InChiKey: HBKBXFQGFPIMOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  46.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-溴噻吩 、 2-ethynyl-1,4-dimethoxybenzene 在 palladium dichloride copper(l) iodide 、 三乙胺 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 以40%的产率得到3-((2,5-dimethoxyphenyl)ethynyl)thiophene
  参考文献：
  名称：

  Preparation and characterisation of a quinone-functionalised polythiophene film on a modified electrode. Application to the potentiometric determination of glutathione and cysteine concentrations

  摘要：

  The new compound 3-((2,5-dimethoxyphenyl)ethynyl)thiophene has been synthesised by Sonogashira coupling. A modified electrode coated with a polythiophene film hearing a quinone moiety was obtained by electropolymerisation of the thienyl group followed by anodic oxidation of para-dimethoxyphenyl group. The cyclovoltammetric response resulting from the reaction of glutathione with the benzoquinone moiety was investigated. The responses of the modified electrode as a new potentiometric sensor of reduced thiols are proposed. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.07.041

文献信息

• Label free biosensors, gram-negative bacteria detection, and real-time and end point determination of antibiotic effects
  申请人：Oakland University

  公开号：US10287616B2

  公开（公告）日：2019-05-14

  Real-time and end point determination of antibiotic effects are disclosed herein. In one example, a surface of a label free biosensor is exposed to a sample including a gram-negative bacteria. A frequency and/or a current of the biosensor is then allowed to reach a constant value. The surface of the biosensor is then exposed to an antibiotic. Using the biosensor, i) a frequency change versus time and a damping resistance versus time, or ii) a current versus voltage or the current versus time at a fixed potential, or iii) both i and ii are then measured. The frequency change versus time and the damping resistance versus time and/or the current versus voltage or the current versus time are correlated to determine an effect of the antibiotic on the gram-negative bacteria. Examples of the label free biosensors and methods for detecting gram-negative bacteria using the label free biosensors are also disclosed.

  本文公开了抗生素效果的实时和终点测定。在一个例子中，无标记生物传感器的表面暴露于包括革兰氏阴性细菌在内的样本中。然后让生物传感器的频率和/或电流达到恒定值。然后将生物传感器的表面暴露在抗生素中。然后使用该生物传感器测量 i) 频率变化与时间的关系和阻尼电阻与时间的关系，或 ii) 电流与电压的关系或固定电位下电流与时间的关系，或 iii) i 和 ii 的关系。将频率变化与时间、阻尼电阻与时间和/或电流与电压或电流与时间相关联，以确定抗生素对革兰氏阴性细菌的影响。此外，还公开了无标记生物传感器的实例以及使用无标记生物传感器检测革兰氏阴性细菌的方法。
• LABEL FREE BIOSENSORS, GRAM-NEGATIVE BACTERIA DETECTION, AND REAL-TIME AND END POINT DETERMINATION OF ANTIBIOTIC EFFECTS
  申请人：Oakland University

  公开号：US20160355866A1

  公开（公告）日：2016-12-08

  Real-time and end point determination of antibiotic effects are disclosed herein. In one example, a surface of a label free biosensor is exposed to a sample including a gram-negative bacteria. A frequency and/or a current of the biosensor is then allowed to reach a constant value. The surface of the biosensor is then exposed to an antibiotic. Using the biosensor, i) a frequency change versus time and a damping resistance versus time, or ii) a current versus voltage or the current versus time at a fixed potential, or iii) both i and ii are then measured. The frequency change versus time and the damping resistance versus time and/or the current versus voltage or the current versus time are correlated to determine an effect of the antibiotic on the gram-negative bacteria. Examples of the label free biosensors and methods for detecting gram-negative bacteria using the label free biosensors are also disclosed.