2-(3-羟基-3-甲基-1-丁炔基)-6-碘-4-(甲氧基甲氧基)吡啶 | 1032413-40-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-(3-羟基-3-甲基-1-丁炔基)-6-碘-4-(甲氧基甲氧基)吡啶
• 英文名称: 2-(3-hydroxy-3-methyl-1-butynyl)-6-iodo-4-(methoxymethoxy)pyridine
• CAS: 1032413-40-3
• 化学式: C₁₂H₁₄INO₃
• 分子量: 347.153
• InChiKey: ODNQZWQFIULMIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.79
• 重原子数：
  17.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  51.58
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2-(3-羟基-3-甲基-1-丁炔基)-6-碘-4-(甲氧基甲氧基)吡啶 、 2-(1-dodecynyl)-6-ethynyl-4-octoxypyridine 在 四(三苯基膦)钯 copper(l) iodide 、 二异丙胺 作用下， 反应 17.0h， 以100%的产率得到4-(6-((6-(dodec-1-yn-1-yl)-4-(octyloxy)pyridin-2-yl)ethynyl)-4-(methoxymethoxy)pyridin-2-yl)-2-methylbut-3-yn-2-ol
  参考文献：
  名称：

  Saccharide Recognition-Induced Transformation of Pyridine−Pyridone Alternate Oligomers from Self-Dimer to Helical Complex

  摘要：

  Co-oligomers involving (1H)-4-pyridone and 4-alkoxypyridine rings were studied, and it was found that their supramolecular transformation was caused by saccharide recognition-In the co-oligomers, pyridone and pyridine rings are alternately linked at their 2,6-position with an acetylene bond. The pyridine rings behave as a hydrogen bonding acceptor, and the pyridone rings and tautomerized 4-pyridinol work as a donor. Pyridine-pyridone-pyridine 3-mer was found to self-dimerize on the basis of vapor pressure osmometry in CHCl3, and the association constant was obtained as 2.3 x 10(3) M-1 by H-1 NMR titration. Longer 5-, 7-, 9-, and 11-mer oligomers showed considerable broadening and anisotropy in the H-1 NMR spectra due to self-association. These longer oligomers recognized octyl beta-D-glucopyranoside and changed their form into a chiral helical complex, showing characteristic circular dichroism.

  DOI：

  10.1021/jo800599w
• 作为产物：
  描述：

  2,6-二碘-4-(甲氧基甲氧基)吡啶 、 2-甲基-3-丁炔-2-醇 在 tris(dibenzylideneacetone)dipalladium(0) chloroform complex copper(l) iodide 、 二异丙胺 、 三(邻甲基苯基)磷 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以100%的产率得到2-(3-羟基-3-甲基-1-丁炔基)-6-碘-4-(甲氧基甲氧基)吡啶
  参考文献：
  名称：

  Saccharide Recognition-Induced Transformation of Pyridine−Pyridone Alternate Oligomers from Self-Dimer to Helical Complex

  摘要：

  Co-oligomers involving (1H)-4-pyridone and 4-alkoxypyridine rings were studied, and it was found that their supramolecular transformation was caused by saccharide recognition-In the co-oligomers, pyridone and pyridine rings are alternately linked at their 2,6-position with an acetylene bond. The pyridine rings behave as a hydrogen bonding acceptor, and the pyridone rings and tautomerized 4-pyridinol work as a donor. Pyridine-pyridone-pyridine 3-mer was found to self-dimerize on the basis of vapor pressure osmometry in CHCl3, and the association constant was obtained as 2.3 x 10(3) M-1 by H-1 NMR titration. Longer 5-, 7-, 9-, and 11-mer oligomers showed considerable broadening and anisotropy in the H-1 NMR spectra due to self-association. These longer oligomers recognized octyl beta-D-glucopyranoside and changed their form into a chiral helical complex, showing characteristic circular dichroism.

  DOI：

  10.1021/jo800599w