1-[2-deoxy-3,5-di-O-(toluoyl)-β-D-ribofuranosyl]-4-iodo-pyrrolo[2,3-b]pyridine | 940949-57-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[2-deoxy-3,5-di-O-(toluoyl)-β-D-ribofuranosyl]-4-iodo-pyrrolo[2,3-b]pyridine
• 英文别名: [(2R,3S,5R)-5-(4-iodopyrrolo[2,3-b]pyridin-1-yl)-3-(4-methylbenzoyl)oxyoxolan-2-yl]methyl 4-methylbenzoate
• CAS: 940949-57-5
• 化学式: C₂₈H₂₅IN₂O₅
• 分子量: 596.421
• InChiKey: CBIMRJQSBWXNOK-ISJGIBHGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  79.6
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-[2-deoxy-3,5-di-O-(toluoyl)-β-D-ribofuranosyl]-4-iodo-pyrrolo[2,3-b]pyridine 、 在 bis-triphenylphosphine-palladium(II) chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  NOVEL ARTIFICIAL FLUORESCENT BASES

  摘要：

  公开号：

  EP2487180B1
• 作为产物：
  描述：

  4-氯-7-氮杂吲哚 在 sodium hydride 、 sodium iodide 作用下， 以 乙腈 、 mineral oil 为溶剂， 反应 14.75h， 生成 1-[2-deoxy-3,5-di-O-(toluoyl)-β-D-ribofuranosyl]-4-iodo-pyrrolo[2,3-b]pyridine
  参考文献：
  名称：

  NOVEL ARTIFICIAL FLUORESCENT BASES

  摘要：

  公开号：

  EP2487180B1

文献信息

• METHOD FOR REPLICATING NUCLEIC ACIDS AND NOVEL UNNATURAL BASE PAIRS
  申请人：Hirao Ichiro

  公开号：US20100036111A1

  公开（公告）日：2010-02-11

  The present invention relates to a method for nucleic acid replication and novel artificial base pairs. The method of the present invention for nucleic acid replication is characterized in that a deoxyribonucleoside 5′-triphosphate, in which the hydroxyl group of phosphoric acid at the γ-position is substituted with a group selected from the group consisting of an amino group, a methylamino group, a dimethylamino group, a mercapto group and a fluoro group, is used as a substrate during replication reaction. The novel artificial base pairs of the present invention are characterized in that 7-(2-thienyl)-imidazo[4,5-b]pyridine (Ds) or an analog thereof forms a base pair with pyrrole-2-carbaldehyde (Pa) or an analog thereof.

  本发明涉及一种核酸复制方法和新型人工碱基对。本发明的核酸复制方法的特征在于，在复制反应过程中使用一种脱氧核苷酸5'-三磷酸作为底物，其中磷酸γ-位置的羟基被从以下群组中选择的一种群组所取代，所述群组包括氨基、甲基氨基、二甲基氨基、巯基和氟基。本发明的新型人工碱基对的特征在于，7-(2-噻吩基)-咪唑并[4,5-b]吡啶（Ds）或其类似物与吡咯-2-甲醛（Pa）或其类似物形成一对碱基。
• ARTIFICIAL BASE PAIR CAPABLE OF FORMING SPECIFIC BASE PAIR
  申请人：Hirao Ichiro

  公开号：US20120231462A1

  公开（公告）日：2012-09-13

  The present invention provides a double-stranded nucleic acid in which at least one nucleic acid strand includes an unnatural base that forms a self-complementary base pair or an unnatural base that forms a base pair with any natural base with substantially the same thermal stability. The present invention also provides a method of hybridizing a first nucleic acid strand with a second nucleic acid strand, wherein the first nucleic acid strand includes an unnatural base that forms a self-complementary base pair or an unnatural base that forms a base pair with any natural base with substantially the same thermal stability, and a method of applying the nucleic acid to SNP detection, a DNA chip, DNA/RNA computing, or an in vitro translation system. The present invention provides a method of introducing an unnatural base into a nucleic acid strand and thereby controlling the thermodynamic stability in hybridization of the nucleic acid strand.

  本发明提供一种双链核酸，其中至少一个核酸链包括一种不自然碱基，该碱基形成自补碱基对或与任何天然碱基形成具有基本相同热稳定性的碱基对。本发明还提供了一种将第一核酸链与第二核酸链杂交的方法，其中第一核酸链包括一种形成自补碱基对或与任何天然碱基形成具有基本相同热稳定性的不自然碱基，以及将该核酸应用于SNP检测、DNA芯片、DNA/RNA计算或体外翻译系统的方法。本发明提供了一种将不自然碱基引入核酸链中并从而控制核酸链杂交的热力学稳定性的方法。
• METHOD FOR NUCLEIC ACID REPLICATION AND NOVEL ARTIFICIAL BASE PAIRS
  申请人：Riken

  公开号：EP1970445A1

  公开（公告）日：2008-09-17

  The present invention relates to a method for nucleic acid replication and novel artificial base pairs. The method of the present invention for nucleic acid replication is characterized in that a deoxyribonucleoside 5'-triphosphate, in which the hydroxyl group of phosphoric acid at the γ-position is substituted with a group selected from the group consisting of an amino group, a methylamino group, a dimethylamino group, a mercapto group and a fluoro group, is used as a substrate during replication reaction. The novel artificial base pairs of the present invention are characterized in that 7-(2-thienyl)-imidazo[4,5-b]pyridine (Ds) or an analog thereof forms a base pair with pyrrole-2-carbaldehyde (Pa) or an analog thereof.

  本发明涉及一种核酸复制方法和新型人工碱基对。 本发明的核酸复制方法的特征在于，在复制反应中使用脱氧核苷 5'-三磷酸作为底物，其中磷酸在 γ 位上的羟基被选自氨基、甲氨基、二甲氨基、巯基和氟基的基团取代。本发明的新型人工碱基对的特征在于，7-(2-噻吩基)-咪唑并[4,5-b]吡啶（Ds）或其类似物与吡咯-2-甲醛（Pa）或其类似物形成碱基对。
• US8030478B2
  申请人：——

  公开号：US8030478B2

  公开（公告）日：2011-10-04
• US8895712B2
  申请人：——

  公开号：US8895712B2

  公开（公告）日：2014-11-25