3-Amino-6-brom-pyrazin-2-carbonsaeure-guanidid | 3377-48-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-Amino-6-brom-pyrazin-2-carbonsaeure-guanidid
• 英文别名: 3-amino-6-bromo-pyrazine-2-carboxylic acid carbamimidoylamide；N-amidino-3-amino-6-bromopyrazinecarboxamide；3-amino-6-bromo-N-(diaminomethylidene)pyrazine-2-carboxamide
• CAS: 3377-48-8
• 化学式: C₆H₇BrN₆O
• 分子量: 259.065
• InChiKey: PNXXYMLGEYCSDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  133
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Use of amiloride and other pyrazine derivatives for preventing or treating ocular neovascularization
  申请人：CELTRIX PHARMACEUTICALS, INC.

  公开号：EP0451130A2

  公开（公告）日：1991-10-09

  A method and composition for preventing and/or treating ocular (including corneal, iridial, retinal, and choroidal) neovascularization in a patient comprises administration of a compound in the class of pyrazine derivative, e.g. amiloride, or one of its derivatives or congeners or one of their pharmaceutically acceptable salts and/or solvates, to the patient. The pyrazine derivatives can be administered by topical administration to ocular tissues with a suitable carrier such as an artificial tear carrier or a petroleum-based ointment, among others. The pyrazine derivative can also be administered orally, by intravenous administration, or by an intraocular implant.

  一种用于预防和/或治疗患者眼部（包括角膜、虹膜、视网膜和脉络膜）新生血管的方法和组合物包括向患者施用吡嗪衍生物类化合物，例如阿米洛利或其衍生物或同系物之一或其药学上可接受的盐和/或溶液之一。吡嗪衍生物可以通过适当的载体，如人工泪液载体或石油基软膏等，局部给药到眼部组织。吡嗪衍生物也可以通过口服、静脉注射或眼内植入的方式给药。