2-Aminomethyl-5-(dimethylaminomethyl)furan oxalic acid salt | 515162-21-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Aminomethyl-5-(dimethylaminomethyl)furan oxalic acid salt
• 英文别名: [5-[(dimethylamino)methyl]furan-2-yl]methanamine;oxalic acid
• CAS: 515162-21-7
• 化学式: C10H16N2O5
• 分子量: 244.24
• InChiKey: RNUOWAUCDJPLRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.04
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate 、 5'-(cyclopropanecarbonyl-amino)-2'-methyl-biphenyl-4-carboxylic acid 、 1-羟基苯并三唑 、 2-Aminomethyl-5-(dimethylaminomethyl)furan oxalic acid salt 、 N,N-二异丙基乙胺 在 氮 、 N,N-二甲基甲酰胺 、 二氯甲烷 、 disodium;carbonate 、 Si 、 乙醚 、 乙酸乙酯 、 乙腈 、 丙酮 、 乙醇 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 18.08h， 以to give the N3-cyclopropyl-N4′-({5-[(dimethylamino)methyl]-2-furyl}methyl)-6-methyl-1,1′-biphenyl-3,4′-dicarboxamide (35 mg, 0.081 mmol)的产率得到n3-Cyclopropyl-n4'-({5-[(dimethylamino)methyl]-2-furyl}methyl)-6-methyl-1,1'-biphenyl-3,4'-dicarboxamide
  参考文献：
  名称：

  5'-carbamoyl-1,1' biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors

  摘要：

  式(I)的化合物，或其药学上可接受的盐或溶剂合物，并且它们作为药物的用途，特别是作为p38激酶抑制剂。

  公开号：

  US20050038014A1

文献信息

• 5′-carbamoyl-1,1′-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors
  申请人：Glaxo Group Limited

  公开号：US07396843B2

  公开（公告）日：2008-07-08

  Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.

  式(I)的化合物，或其药学上可接受的盐或溶剂，以及它们作为药物的用途，特别是作为p38激酶抑制剂。
• 5'-CARBAMOYL-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS
  申请人：GLAXO GROUP LIMITED

  公开号：EP1435942A1

  公开（公告）日：2004-07-14
• US7396843B2
  申请人：——

  公开号：US7396843B2

  公开（公告）日：2008-07-08
• [EN] 5'-CARBAMOYL-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS<br/>[FR] DERIVES DE 5'CARBAMOYL-1,1'-BIPHENYL-4-CARBOXAMIDE ET LEUR UTILISATION COMME INHIBITEURS DE LA KINASE P38
  申请人：GLAXO GROUP LTD

  公开号：WO2003032980A1

  公开（公告）日：2003-04-24

  Compounds of formula (I): wherein X is a bond or a phenyl group which may be optionally substituted; R1 is selected from an optionally substituted five- to seven-membered heterocyclic ring, an optionally substituted five- to seven-membered heteroaryl ring and an optionally substituted fused bicyclic ring; R2 is selected from hydrogen, C1-6 alkyl and -(CH2)p-C3-7cycloalkyl; or when X is a bond and m and n are both zero R1 and R2, together with the nitrogen atom to which they are bound, form a five- to six-membered heterocyclic ring optionally containing one additional heteroatom selected from oxygen and nitrogen, which can be optionally substituted by C1-4alkyl; R3 is the group -CO-NH-(CH2)q-R4; U is selected from methyl and halogen; W is selected from methyl and chlorine; V and Y are each selected independently from hydrogen, methyl and halogen; Z is selected from -O- and a bond; m and n are independently selected from 0, 1 and 2, wherein each carbon atom of the resulting carbon chain may be optionally substituted with up to two groups selected independently from C1-6alkyl, and the sum of m+ n is from 0 to 4; p is selected from 0 and 1; q and s are selected from 0, 1 and 2; r is selected from 0, 1 and 2; or pharmaceutically acceptable salts or solvated thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.