2-(2,4-bis(trifluoromethyl)phenyl)-5-methylpyridine | 1494718-14-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(2,4-bis(trifluoromethyl)phenyl)-5-methylpyridine
• 英文别名: 2-[2,4-Bis(trifluoromethyl)phenyl]-5-methylpyridine；2-[2,4-bis(trifluoromethyl)phenyl]-5-methylpyridine
• CAS: 1494718-14-7
• 化学式: C₁₄H₉F₆N
• 分子量: 305.223
• InChiKey: AANIFXNHLOTELL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.09
• 重原子数：
  21.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  12.89
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  2-(2,4-bis(trifluoromethyl)phenyl)-5-methylpyridine 在 N-溴代丁二酰亚胺(NBS) 、 过氧化苯甲酰 作用下， 以 四氯化碳 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  Imidazopyridazine Hepatitis C Virus Polymerase Inhibitors. Structure–Activity Relationship Studies and the Discovery of a Novel, Traceless Prodrug Mechanism

  摘要：

  By reducing the basicity of the core heterocycle in a series of HCV NS5B inhibitors, the hERG liability was reduced. The SAR was then systematically explored in order to increase solubility and enable dose escalation while retaining potency. During this exploration, a facile decarboxylation was noted and was exploited as a novel prodnig mechanism. The synthesis and characterization of these prodrugs and their utilization in chronic toxicity studies are presented.

  DOI：

  10.1021/jm401337x
• 作为产物：
  描述：

  5-METHYL-2-PYRIDYLZINC BROMIDE 、 2,4-双(三氟甲基)溴苯 在 四(三苯基膦)钯 作用下， 以 四氢呋喃 为溶剂， 反应 0.17h， 以16%的产率得到2-(2,4-bis(trifluoromethyl)phenyl)-5-methylpyridine
  参考文献：
  名称：

  Imidazopyridazine Hepatitis C Virus Polymerase Inhibitors. Structure–Activity Relationship Studies and the Discovery of a Novel, Traceless Prodrug Mechanism

  摘要：

  By reducing the basicity of the core heterocycle in a series of HCV NS5B inhibitors, the hERG liability was reduced. The SAR was then systematically explored in order to increase solubility and enable dose escalation while retaining potency. During this exploration, a facile decarboxylation was noted and was exploited as a novel prodnig mechanism. The synthesis and characterization of these prodrugs and their utilization in chronic toxicity studies are presented.

  DOI：

  10.1021/jm401337x

文献信息

• A Metallaphotoredox Strategy for the Cross‐Electrophile Coupling of α‐Chloro Carbonyls with Aryl Halides
  作者：Tiffany Q. Chen、David W. C. MacMillan

  DOI：10.1002/anie.201909072

  日期：2019.10.7

  effective for a wide variety of aryl bromide coupling partners, is predicated upon a halogen atom abstraction/nickel radical-capture mechanism that is generically successful across an extensive range of carbonyl substrates. The construction and use of arylacetic acid products have further enabled two-step protocols for the delivery of valuable building blocks for medicinal chemistry, such as aryldifluoromethyl

  在这里，我们证明了金属氧还原催化的亲电子交联机理为多种活化烷基氯的α-芳基化反应提供了统一的方法，包括α-氯酮，α-氯酸酯，α-氯酰胺，α-氯羧酸和苄基氯。 。该策略对多种芳基溴化物偶联伙伴有效，基于卤素原子的提取/镍自由基捕获机制，该机制普遍适用于广泛的羰基底物。芳基丙烯酸产品的构建和使用进一步实现了两步协议，可用于交付药用化学的重要组成部分，例如芳基二氟甲基和二芳基甲烷图案。