[H3Cu(5,7,3'-trihydroxyl-4'-methoxyl-flavanone benzoyl hydrazone)*OAc]*H2O | 1196088-28-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: [H3Cu(5,7,3'-trihydroxyl-4'-methoxyl-flavanone benzoyl hydrazone)*OAc]*H2O
• CAS: 1196088-28-4
• 化学式: C₂₅H₂₂CuN₂O₈*H₂O
• 分子量: 560.02
• InChiKey: IOFPIJOYNWQXHN-PUHAYJMPSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  [Cu2(OAc)4(H2O)2] 、 5,7,3'-trihydroxyl-4'-methoxyl-flavanone benzoyl hydrazone 以 丙酮 为溶剂， 生成 [H3Cu(5,7,3'-trihydroxyl-4'-methoxyl-flavanone benzoyl hydrazone)*OAc]*H2O
  参考文献：
  名称：

  DNA binding affinity and antioxidative activity of copper(II) and zinc(II) complexes with a novel hesperetin Schiff base ligand

  摘要：

  A hesperetin Schiff base ligand (H4L) and its complexes, [H3CuL center dot OAc]center dot H2O and [H3ZnL center dot OAc]center dot 2H(2)O, have been synthesized and characterized on the basis of elemental analysis, molar conductivity, H-1 NMR, mass spectra, UV-Vis spectra and IR spectra. The binding of these two complexes and the ligand to DNA has been investigated by ultraviolet absorption spectroscopy, fluorescence spectroscopy and viscosity measurements. The experiments indicate that all the compounds can bind to DNA through an intercalative mode and the complexes intercalate into DNA more deeply than that of the ligand. In addition, the anti-oxidative activity was also determined. The 50% inhibition obtained for the ligand and its complexes demonstrates that, compared to the ligand, the complexes exhibit higher antioxidative activity in the suppression of O-2(-center dot) and HO center dot. (C) 2009 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2009.07.008

文献信息

• Chelating ability and biological activity of hesperetin Schiff base
  作者：Elzbieta Lodyga-Chruscinska、Marzena Symonowicz、Anna Sykula、Anna Bujacz、Eugenio Garribba、Magdalena Rowinska-Zyrek、Stanislaw Oldziej、Elzbieta Klewicka、Magdalena Janicka、Karolina Krolewska、Marcin Cieslak、Katarzyna Brodowska、Longin Chruscinski

  DOI：10.1016/j.jinorgbio.2014.11.005

  日期：2015.2

  N-[(±)-[5,7-dihydroxy-2-(3-hydroxy-4-methoxy-phenyl)chroman-4-ylidene]amino]benzamide has been synthesized and its crystal structure was determined. This compound was used for the formation of Cu(II) complexes in solid state and in solution which were characterized using different spectroscopic methods. The analyses of potentiometric titration curves revealed that monomeric and dimeric complexes of Cu(II)

  he橙皮素希夫碱（HHSB）— N-[（±）-[5,7-二羟基-2-（3-羟基-4-甲氧基-苯基）苯并吡喃-4-亚烷基]氨基]苯甲酰胺已经合成，并且其晶体确定结构。该化合物用于固态和溶液形式的Cu（II）配合物的形成，使用不同的光谱方法对其进行表征。电位滴定曲线的分析表明，在pH高于7的条件下会形成Cu（II）的单体和二聚体复合物。ESI-MS（电喷雾电离质谱法）光谱证实了它们的形成。EPR和UV可见光谱表明，氧和氮原子参与了Cu（II）的配位。腙橙皮素的席夫碱可以显示酮-烯醇互变异构现象并且在该坐标酮的Cu（II）（O -，N，O KET）和烯醇化物形式（O -，N，O -烯醇）。半经验分子轨道方法PM6和DFT（密度泛函理论）的计算表明，二聚配合物的更稳定形式是其中配体以烯醇形式存在的那一种。CuHHSB复合物已显示出在水溶液中裂解质粒DNA的高效率，表明其具有化学核酸酶的潜力。已经进