4,6-bis(6-(6-methylpyridin-2-yl)pyridin-2-yl)pyrimidine | 856887-77-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4,6-bis(6-(6-methylpyridin-2-yl)pyridin-2-yl)pyrimidine
• 英文别名: 4,6-bis[6-(6-methylpyridin-2-yl)pyridin-2-yl]pyrimidine；4,6-Bis[6-(6-methylpyridin-2-yl)pyridin-2-yl]pyrimidine
• CAS: 856887-77-9
• 化学式: C₂₆H₂₀N₆
• 分子量: 416.485
• InChiKey: NOGVWBBWKGJCLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  77.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4,6-bis(6-(6-methylpyridin-2-yl)pyridin-2-yl)pyrimidine 在 chromium(VI) oxide 、 氯化亚砜 、 硫酸 作用下， 反应 24.0h， 生成 6-(6-(6-(6-(6-(chlorocarbonyl)pyridin-2-yl)pyridin-2-yl)pyrimidin-4-yl)pyridin-2-yl)pyridine-2-carbonyl chloride
  参考文献：
  名称：

  Preparation of new heterotopic ligands

  摘要：

  A six-step synthesis of two new heterotopic ligands, each possessing two unusual N,N,N,O tetradentate binding Subunits, has been developed. This work presents a particularly facile and rapid synthetic protocol for the preparation of these ligands, which one expected to act as useful components in inorganic self-assembly for the preparation of various types of complexes. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.03.131
• 作为产物：
  描述：

  2-(6-methylpyridin-2-yl)-6-(trimethylstannyl)pyridine 、 4,6-二氯嘧啶 在 四(三苯基膦)钯 、 lithium chloride 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以0.42 g的产率得到4,6-bis(6-(6-methylpyridin-2-yl)pyridin-2-yl)pyrimidine
  参考文献：
  名称：

  Preparation of new heterotopic ligands

  摘要：

  A six-step synthesis of two new heterotopic ligands, each possessing two unusual N,N,N,O tetradentate binding Subunits, has been developed. This work presents a particularly facile and rapid synthetic protocol for the preparation of these ligands, which one expected to act as useful components in inorganic self-assembly for the preparation of various types of complexes. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.03.131

文献信息

• Quaterpyridine Ligands Forming Helical Complexes of Mono‐ and Dinuclear (Helicate) Forms
  作者：Artur R. Stefankiewicz、Monika Wałęsa、Piotr Jankowski、Artur Ciesielski、Violetta Patroniak、Maciej Kubicki、Zbigniew Hnatejko、Jack M. Harrowfield、Jean‐Marie Lehn

  DOI：10.1002/ejic.200800172

  日期：2008.6

  The dimethylquaterpyridine ligand L1 reacts with CuI and AgI to give dinuclear complexes of “helicate” form, in which the metals are in an approximate tetrahedral coordination, whereas reactions with CoII and ZnII provide mononuclear complexes, in which the metals are apparently six-coordinate with markedly distorted octahedral coordination, and the ligand retains a helical conformation. Oxidation of

  二甲基季吡啶配体 L1 与 CuI 和 AgI 反应生成“螺旋”形式的双核配合物，其中金属呈近似四面体配位，而与 CoII 和 ZnII 的反应提供单核配合物，其中金属显然与八面体配位明显扭曲，配体保持螺旋构象。L1 的甲基取代基氧化成羧酸基团，然后酯化，得到配体 L2，它也形成双核 CuI 螺旋和单核 CoII 复合物；其中一个酯基似乎与后者的络合有关。所有配合物均通过单晶 X 射线结构测定进行表征。 (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
• Preparation of new heterotopic ligands
  作者：Violetta Patroniak、Maciej Kubicki、Artur R. Stefankiewicz、Agnieszka M. Grochowska

  DOI：10.1016/j.tet.2005.03.131

  日期：2005.6

  A six-step synthesis of two new heterotopic ligands, each possessing two unusual N,N,N,O tetradentate binding Subunits, has been developed. This work presents a particularly facile and rapid synthetic protocol for the preparation of these ligands, which one expected to act as useful components in inorganic self-assembly for the preparation of various types of complexes. (c) 2005 Elsevier Ltd. All rights reserved.