2,3,4,5-Tetrafluor-benzolsulfonsaeure | 2070-75-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3,4,5-Tetrafluor-benzolsulfonsaeure
• 英文别名: 2,3,4,5-Tetrafluorobenzene-1-sulfonic acid；2,3,4,5-tetrafluorobenzenesulfonic acid
• CAS: 2070-75-9
• 化学式: C₆H₂F₄O₃S
• 分子量: 230.14
• InChiKey: OUXGBSWADJDIMN-UHFFFAOYSA-N

物化性质

• 熔点：
  73-74 °C
• 密度：
  1.783±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  三甲基氯硅烷 、 2,3,4,5-Tetrafluor-benzolsulfonsaeure 生成 trimethylsilyl 2,3,4,5-tetrafluorobenzenesulfonate
  参考文献：
  名称：

  Fluor-Benzolsulfonsäuretrimethylsilylester

  摘要：

  三甲基硅醇酯的氟苯磺酸 通过氟苯的电亲核磺化反应制备了氟苯磺酸。这些酸以水合物的形式获得，并转化为其三甲基硅醇酯以进行表征。

  DOI：

  10.1055/s-1988-27668
• 作为产物：
  描述：

  四氟苯 在 三氧化硫 作用下， 反应 10.0h， 生成 2,3,4,5-Tetrafluor-benzolsulfonsaeure
  参考文献：
  名称：

  Fluor-Benzolsulfonsäuretrimethylsilylester

  摘要：

  三甲基硅醇酯的氟苯磺酸 通过氟苯的电亲核磺化反应制备了氟苯磺酸。这些酸以水合物的形式获得，并转化为其三甲基硅醇酯以进行表征。

  DOI：

  10.1055/s-1988-27668

文献信息

• RADICAL POLYMERIZATION INITIATOR, COMPOSITION CONTAINING SAME, CURED PRODUCT OF COMPOSITION, PRODUCTION METHOD FOR CURED PRODUCT, AND COMPOUND
  申请人：ADEKA CORPORATION

  公开号：US20210107887A1

  公开（公告）日：2021-04-15

  Provided are: a radical polymerization initiator which has excellent sensitivity and solubility in water; a composition containing the same; a cured product of the composition; a method of producing the cured product; and a compound. The radical polymerization initiator contains a compound represented by Formula (A) below (wherein Z 1 represents a direct bond or the like; Z 2 represents >CR 102 2 or the like; R 1 to R 8 each represent a hydrogen atom or the like, or a group containing a salt-forming group, which is represented by Formula (B1) below (wherein L 1 represents a direct bond or the like, B represents an acidic group salt or the like, b represents 1 to 10, and the asterisk (*) represents a binding site); at least one of R 1 to R 8 is the group containing a salt-forming group; R 101 and the like each represent a hydrogen atom or the like; one or more hydrogen atoms in the alkyl group and the like used as R 1 to R 8 and the like are optionally substituted with an ethylenically unsaturated group or the like; one or more methylene groups in R 1 to R 8 and the like are optionally substituted with a double bond or the like; adjacent groups such as R 1 and R 2 are optionally bound together to form a ring and optionally form a fused ring with a benzene ring in Formula (A); and R′ represents a hydrogen atom or the like).

  提供了：具有优异灵敏度和水溶性的自由基聚合引发剂；含有该引发剂的组合物；该组合物的固化产物；生产该固化产物的方法；以及一种化合物。自由基聚合引发剂包含以下式（A）所代表的化合物（其中Z1代表直接键或类似物；Z2代表>CR1022或类似物；R1至R8各自代表氢原子或类似物，或者包含盐形成基团的群，该基团由下式（B1）代表（其中L1代表直接键或类似物，B代表酸性基团盐或类似物，b代表1至10，星号（*）代表结合位）；R1至R8中至少有一个是包含盐形成基团的群；R101等各自代表氢原子或类似物；R1至R8等中所用的烷基群等中的一个或多个氢原子可以选择性地被乙烯不饱和基团等替代；R1至R8等中的一个或多个亚甲基群可以选择性地被双键等替代；相邻的群，如R1和R2，可以选择性地结合在一起形成环，并且可以选择性地与式（A）中的苯环形成融合环；R′代表氢原子或类似物）。
• [EN] ANTIBODY-DRUG CONJUGATES (ADCS) COMPRISING AN ANTI-TROP-2 ANTIBODY, COMPOSITIONS COMPRISING SUCH ADCS, AS WELL AS METHODS OF MAKING AND USING THE SAME<br/>[FR] CONJUGUÉS ANTICORPS-MÉDICAMENT (ADC) COMPRENANT UN ANTICORPS ANTI-TROP-2, COMPOSITIONS COMPRENANT DE TELS ADC, AINSI QUE PROCÉDÉS DE FABRICATION ET D'UTILISATION DE CEUX-CI
  申请人：LEVENA SUZHOU BIOPHARMA CO LTD

  公开号：WO2021225892A1

  公开（公告）日：2021-11-11

  This disclosure relates to antibody-drug conjugates (ADCs) comprising an anti-Trop-2 antibody. Provided herein are compositions comprising such ADCs, as well as methods of making and using the same.

  本公开涉及包含抗Trop-2抗体的抗体药物偶联物（ADCs）。本文提供了包含这种ADCs的组合物，以及制备和使用这些组合物的方法。
• AROMATIC SULFONIUM SALT COMPOUND
  申请人：Makabe Yoshie

  公开号：US20120130117A1

  公开（公告）日：2012-05-24

  Disclosed is a photo-acid generator having high developing properties, a cationic polymerization initiator having high curing properties, and a resist composition and a cationically polymerizable composition containing the photo-acid generator and the cationic polymerization initiator, respectively. Specifically, disclosed is an aromatic sulfonium salt compound of general formula (I) and a photo-acid generator, a cationic polymerization initiator, a resist composition, and a cationically polymerizable composition containing the compound. In formula (I), R 1 to R 19 are each hydrogen, halogen, hydroxyl, optionally hydroxyl-substituted C1-C18 alkyl, optionally hydroxyl-substituted C1-C18 alkoxy, optionally hydroxyl-substituted C1-C18 thioalkoxy, etc.; An − is a monovalent anion; at least one of R 1 to R 19 is a substituent selected from the group consisting of hydroxyl, hydroxyl-substituted C1-C12 ester group, hydroxyl-substituted C1-C18 alkoxy, and hydroxyl-substituted C1-C18 thioalkoxy.

  本发明涉及一种具有高显影性能的光酸发生剂，具有高固化性能的阳离子聚合引发剂，以及包含光酸发生剂和阳离子聚合引发剂的抗蚀剂组合物和阳离子聚合组合物。具体地，本发明涉及一种通式（I）的芳香基磺酸盐化合物和光酸发生剂、阳离子聚合引发剂、抗蚀剂组合物和阳离子聚合组合物，其中化合物的R1至R19分别为氢、卤素、羟基、可选的羟基取代的C1-C18烷基、可选的羟基取代的C1-C18烷氧基、可选的羟基取代的C1-C18硫代烷氧基等；An−是一价阴离子；R1至R19中至少有一个是从羟基、羟基取代的C1-C12酯基、羟基取代的C1-C18烷氧基和羟基取代的C1-C18硫代烷氧基组成的取代基。
• [EN] INNATE IMMUNITY KILLER CELLS TARGETING PSMA POSITIVE TUMOR CELLS<br/>[FR] CELLULES TUEUSES D'IMMUNITÉ NATURELLE CIBLANT DES CELLULES TUMORALES POSITIVES AU PSMA
  申请人：SORRENTO THERAPEUTICS INC

  公开号：WO2021178890A1

  公开（公告）日：2021-09-10

  The present disclosure provides an innate immunity cell such as a gamma delta T (gdT) cell, Natural Killer (NK) cell, or macrophage having 2-[3-(1,3-dicarboxypropyl)ureido] pentanedioic acid (DUPA) chemically conjugated to the cell surface. The DUPA-conjugated cells provided herein demonstrate increased cytotoxicity toward cancer cells expressing PSMA. DUPA-conjugated cells can be primary cells or cells of a cell line. Also provided are methods of conjugating DUPA to the surface of NK cells, gamma delta T (gdT) cells, or macrophages and methods of treating cancer using DUPA-conjugated NK cells, gamma delta T (gdT) cells, or macrophages.

  本公开提供了一种天然免疫细胞，例如伽玛-三角洲T（gdT）细胞、自然杀伤（NK）细胞或巨噬细胞，其表面化学偶联有2-[3-(1,3-二羧基丙基)脲基]戊二酸（DUPA）。本文所提供的DUPA偶联细胞对表达PSMA的癌细胞表现出增强的细胞毒性。DUPA偶联细胞可以是原代细胞或细胞系的细胞。还提供了将DUPA偶联到NK细胞、gdT细胞或巨噬细胞表面的方法，以及使用DUPA偶联NK细胞、gdT细胞或巨噬细胞治疗癌症的方法。
• POLYMERIZABLE LIQUID CRYSTAL COMPOSITION, POLARIZED LIGHT-EMITTING COATING MATERIAL, NOVEL NAPHTHOLACTAM DERIVATIVE NOVEL COUMARIN DERIVATIVE, NOVEL NILE RED DERIVATIVE, AND NOVEL ANTHRACENE DERIVATIVE
  申请人：Kubota Yusuke

  公开号：US20130334461A1

  公开（公告）日：2013-12-19

  Provided are a polymerizable liquid crystal composition, a coating material, a medium, and a polarizing device each produced using a polymerizable liquid crystal compound and a colorant and each capable of producing polarized light suitable for polarizing devices, and also a novel naphtholactam derivative, a novel coumarin derivative, a novel Nile Red derivative, and a novel anthracene derivative each suitable for use as the colorant. Specifically provided are a polymerizable liquid crystal composition containing (A) at least one liquid crystal compound having a polymerizable functional group, (B) at least one colorant, and (C) a polymerization initiator, and a novel naphtholactam derivative of formula (IV′), a novel coumarin derivative of formula (VI′), a novel Nile Red derivative of formula (VII′), and a novel anthracene derivative of formula (VIII′) each suitable for use as the colorant (B).

  提供了一种可聚合的液晶组合物、涂料材料、介质和极化装置，每种都使用了聚合液晶化合物和颜料，并且能够产生适合于极化装置的偏振光，还提供了一种新型萘内酰胺衍生物、一种新型香豆素衍生物、一种新型尼罗红衍生物和一种新型蒽衍生物，每种都适用于用作颜料。具体提供了一种聚合液晶组合物，包含（A）至少一种具有聚合功能基团的液晶化合物，（B）至少一种颜料，和（C）聚合引发剂，以及一种适用于用作颜料（B）的新型萘内酰胺衍生物（IV′）, 一种新型香豆素衍生物（VI′）, 一种新型尼罗红衍生物（VII′）和一种新型蒽衍生物（VIII′）。