4-benzoylamino-4'-methyl-1,1'-biphenyl | 1266338-65-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-benzoylamino-4'-methyl-1,1'-biphenyl
• 英文别名: N-(4'-methylbiphenyl-4-yl)benzamide；N-[4-(4-methylphenyl)phenyl]benzamide
• CAS: 1266338-65-1
• 化学式: C₂₀H₁₇NO
• 分子量: 287.361
• InChiKey: SEQQICDVFBDRAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-benzoylamino-4'-methyl-1,1'-biphenyl 、 (2,3-dihydrobenzo[b][1,4]dioxin-6-yl)(mesityl)iodonium tetrafluoroborate 在 copper(II) bis(trifluoromethanesulfonate) 作用下， 以 二氯甲烷 为溶剂， 反应 60.0h， 以51%的产率得到N-(2,6-bis(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4'-methyl-[1,1':2',1''-terphenyl]-4'-yl)benzamide
  参考文献：
  名称：

  联苯胺和联苯胺与二芳基碘鎓盐的酰胺导向的海湾区域两步式π膨胀（APEX）：有效地获得多环芳烃

  摘要：

  已经开发了联苯和三联苯与二芳基碘鎓盐的酰胺导向的海湾区域两步环扩反应。根据该方法可以有效地合成多种多环芳烃，例如三亚苯基，二苯并[ fg，op ]并四苯和三苯并[ fg，ij，rst ]五苯衍生物。

  DOI：

  10.1002/adsc.201901010
• 作为产物：
  描述：

  4-甲苯硼酸 在 四(三苯基膦)钯 、 polystyrene supported morpholine 、 镍 、 sodium carbonate 作用下， 以 乙醇 、 二氯甲烷 、 水 、 乙酸乙酯 、 甲苯 为溶剂， 反应 24.17h， 生成 4-benzoylamino-4'-methyl-1,1'-biphenyl
  参考文献：
  名称：

  Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state

  摘要：

  A biphenyl library incorporating amide and sulfonamide groups has been synthesised via microwave-mediated Suzuki-Miyaura couplings. Many derivatives were crystallised from dichloromethane/methanol and analysed by single crystal X-ray diffraction. An interesting structure was obtained for N-(4'-methylbiphenyl-4-yl)acetamide with Z'=6 and hydrogen-bonding networks of the type N-H center dot center dot center dot O in the unit cell. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.08.062

文献信息

• Palladium-Catalyzed C−H Aminations of Anilides with <i>N</i>-Fluorobenzenesulfonimide
  作者：Kai Sun、Yan Li、Tao Xiong、Jingping Zhang、Qian Zhang

  DOI：10.1021/ja1101695

  日期：2011.2.16

  The first amide-directed, palladium-catalyzed, intermolecular, highly selective C-H aminations with the non-nitrene-based nitrogen source N-fluorobenzenesulfonimide have been developed. This methodology might provide a new pathway for directed metal-catalyzed aromatic C-H amination.

  已经开发出第一个酰胺导向、钯催化、分子间、高选择性 CH 胺化与非氮基氮源 N-氟苯磺酰亚胺。这种方法可能为定向金属催化的芳香族 CH 胺化提供了一条新途径。
• Glycolate oxidase inhibitors for the treatment of disease
  申请人：BIOMARIN PHARMACEUTICAL INC.

  公开号：US11384055B2

  公开（公告）日：2022-07-12

  Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

  本文描述的是化合物、制造此类化合物的方法、含有此类化合物的药物组合物和药剂，以及使用此类化合物治疗或预防与乙醛酸氧化酶（GO）相关的疾病或紊乱的方法。此类疾病或紊乱包括，例如，与产生过量草酸盐有关的乙醛酸代谢紊乱，包括原发性高草酸尿症。
• GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE
  申请人：BIOMARIN PHARMACEUTICAL INC.

  公开号：US20210171474A1

  公开（公告）日：2021-06-10

  Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.