2-cyclohexyl-4-(2-methylpyridin-4-yl)-3-(1H-tetrazol-5-yl)-6-(trifluoromethyl)-5,6,7,8-tetrahydroquinoline | 1569824-97-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-cyclohexyl-4-(2-methylpyridin-4-yl)-3-(1H-tetrazol-5-yl)-6-(trifluoromethyl)-5,6,7,8-tetrahydroquinoline
• 英文别名: 2-cyclohexyl-4-(2-methylpyridin-4-yl)-3-(2H-tetrazol-5-yl)-6-(trifluoromethyl)-5,6,7,8-tetrahydroquinoline
• CAS: 1569824-97-0
• 化学式: C₂₃H₂₅F₃N₆
• 分子量: 442.487
• InChiKey: ALFQKPZYXQRVDU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  80.2
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] ANTIVIRAL USE OF FABP4 MODULATING COMPOUNDS<br/>[FR] UTILISATION ANTIVIRALE DE COMPOSÉS MODULANT LA FABP4
  申请人：CRESCENTA BIOSCIENCES

  公开号：WO2022010951A1

  公开（公告）日：2022-01-13

  A method for treating a viral disease in a subject comprising administering to said subject a therapeutically effective dose of one or more compounds that bind to fatty acid binding protein FABP4, with compounds described in the specification some having the general formula, Formula I-Formula XII, where W1 – W4 Z1-Z4 Z1 – Z5 X, Y, n, and R1 – R8 are as defined in the claims and description of embodiments. In examples, the ring Z contains Z1-Z4. In other examples, the ring Z contains Z1-Z5. (I)

  一种治疗受试者病毒性疾病的方法，包括向该受试者投予治疗有效剂量的一个或多个结合到脂肪酸结合蛋白FABP4的化合物，其中所述化合物在说明书中被描述，其中一些具有一般式I-式XII，其中W1-W4，Z1-Z4，Z1-Z5，X，Y，n和R1-R8如权利要求和实施例的描述中所定义。在示例中，环Z包含Z1-Z4。在其他示例中，环Z包含Z1-Z5。（I）
• NEW BICYCLICPYRIDINE DERIVATIVES
  申请人：HOFFMANN-LA ROCHE INC.

  公开号：US20150368256A1

  公开（公告）日：2015-12-24

  The invention provides novel compounds having the general formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , A 1 , A 2 , A 3 , m, n and p are as described herein, compositions including the compounds and methods of using the compounds.

  本发明提供了具有一般式（I）的新化合物，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、A1、A2、A3、m、n和p如本文所述，包括该化合物的组合物和使用该化合物的方法。
• FABP4 as a therapeutic target in skin diseases
  申请人：TICURE LTD.

  公开号：US11229624B2

  公开（公告）日：2022-01-25

  Provided are methods of regulating proliferation and/or differentiation of keratinocytes and immune cells, more specifically to methods of treating pathologies characterized by hyperproliferative keratinocytes or inflammatory skin diseases by administration of FABP4-inhibitor.

  本发明提供了调节角质细胞和免疫细胞增殖和/或分化的方法，更具体地说，提供了通过服用 FABP4 抑制剂治疗以角质细胞过度增殖或炎症性皮肤病为特征的病症的方法。
• FABP4 AS A THERAPEUTIC TARGET IN SKIN DISEASES
  申请人：TICURE LTD.

  公开号：US20200138779A1

  公开（公告）日：2020-05-07

  Provided are methods of regulating proliferation and/or differentiation of keratinocytes and immune cells, more specifically to methods of treating pathologies characterized by hyperproliferative keratinocytes or inflammatory skin diseases by administration of FABP4-inhibitor.
• US9562052B2
  申请人：——

  公开号：US9562052B2

  公开（公告）日：2017-02-07