bis-(3-methoxy-benzyl)-methyl-amine | 148234-87-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis-(3-methoxy-benzyl)-methyl-amine
• 英文别名: N-methyl-N,N-bis(3-methoxybenzyl)amine；N,N-Di(3-Anisyl)-N-methylamine；1-(3-methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-N-methylmethanamine
• CAS: 148234-87-1
• 化学式: C₁₇H₂₁NO₂
• 分子量: 271.359
• InChiKey: OVSVJJOCWPIPDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 N,N-bis(m-methoxybenzyl)amine 在 palladium-carbon 作用下， 以 甲醇 为溶剂， 生成 bis-(3-methoxy-benzyl)-methyl-amine
  参考文献：
  名称：

  EP613879

  摘要：

  公开号：

文献信息

• Initiator system containing a diarylalkylamine derivate, hardenable composition and use thereof
  申请人：3M Innovative Properties Company

  公开号：EP2133064A1

  公开（公告）日：2009-12-16

  The invention relates to an initiatorsystem comprising a diarylalkylamine compound and a sensitizing agent. The invention also relates to a hardenable composition comprising the initiator system. The invention further relates to the use of the initiatorsystem for initiating the hardening process of a hardenable composition being selected from cationically curing composition(s) and/or radically curing composition(s) or a mixture thereof. The initiator system and the hardening composition can be used in various fields, including the dental and orthodontic area.

  本发明涉及一种包括二芳基烷基胺化合物和感光剂的引发剂系统。本发明还涉及一种可硬化组合物，其中包括该引发剂系统。本发明进一步涉及使用该引发剂系统来启动从阳离子固化组合物和/或自由基固化组合物或两者的混合物中选择的可硬化组合物的硬化过程。该引发剂系统和可硬化组合物可在各个领域中使用，包括牙科和正畸领域。
• INITIATOR SYSTEM CONTAINING A DIARYLALKYLAMINE DERIVATE, HARDENABLE COMPOSITION AND USE THEREOF
  申请人：Hailand Bettina

  公开号：US20110077361A1

  公开（公告）日：2011-03-31

  The invention relates to an initiator system comprising a diarylalkylamine compound and a sensitizing agent. The invention also relates to a hardenable composition comprising the initiator system. The invention further relates to the use of the initiator system for initiating the hardening process of a hardenable composition being selected from cationically curing composition(s) and/or radically curing composition(s) or a mixture thereof. The initiator system and the hardening composition can be used in various fields, including the dental and orthodontic area.

  本发明涉及一种包括二芳基烷基胺化合物和增感剂的引发剂系统。本发明还涉及一种可硬化组合物，该组合物包括引发剂系统。本发明进一步涉及使用引发剂系统来启动从阳离子固化组合物和/或自由基固化组合物或其混合物中选择的可硬化组合物的硬化过程。引发剂系统和硬化组合物可用于各种领域，包括牙科和正畸领域。
• PHELLODENDRINE ANALOGS AND ALLERGY TYPE IV SUPPRESSOR CONTAINING THE SAME AS ACTIVE INGREDIENT
  申请人：TSUMURA & CO.

  公开号：EP0613879A1

  公开（公告）日：1994-09-07

  Phellodendrine analogs represented by general formula (I), wherein A represents the group (a); B represents hydrogen, lower alkyl or lower acyl, or alternatively A and B together with the adjacent nitrogen atom form a substituted 1,2,3,4-tetrahydroisoquinoline ring represented by general formula (II), R₁₁, R₁₂, R₂₁, R₂₂, R₃₁ and R₃₂ represent each hydrogen, hydroxyl or lower alkoxy; n₁ represents a number of 0 to 2; n₂ represents a number of 1 and 2; and m₁ represents a number of 0 to 1, provided tsat when A represents the group (b), and n₂ is 2, B is lower acyl, and that when A and B together form a substituted 1,2,3,4-tetrahydroisoquinoline ring, n₁ is 1 and m₁ is not 0. These analogs (I) and related compounds have an excellent activity of suppressing allergy type IV and hence are utilizable as a medicine efficacious against diseases wherein allergy type IV participates, such as chronic hepatitis, intractable asthma, nephrotic syndrome or rheumatism.

  通式(I)代表的黄柏碱类似物，其中 A 代表基团(a)；B 代表氢、低级烷基或低级酰基，或者 A 和 B 与相邻的氮原子一起形成取代的 1,2,3,4-四氢异喹啉环、R₁₁、R₁₂、R₂₁、R₂₂、R₃₁ 和 R₃₂ 分别代表氢、羟基或低级烷氧基；n₁ 代表 0 至 2；n₂ 代表 1 和 2；m₁ 代表 0 至 1，条件是当 A 代表基团(b)，且 n₂ 为 2 时，B 为低级酰基，且当 A 和 B 共同形成取代的 1，2，3，4-四氢异喹啉环时，n₁ 为 1，m₁ 不是 0。这些类似物（I）和相关化合物具有抑制 IV 型过敏的优异活性，因此可用作对 IV 型过敏参与的疾病（如慢性肝炎、难治性哮喘、肾病综合征或风湿病）有效的药物。
• Reductive Aminomethylation Using Ammonium Formate and Methanol as N1 and C1 Source: Direct Synthesis of Mono- and Di-Methylated Amines
  作者：Ishani Borthakur、Srabani Nandi、Yuvraj Bilora、Biswajit Sadhu、Sabuj Kundu

  DOI：10.1021/acscatal.4c00346

  日期：2024.4.19

  single and dual reductive amination followed by N-methylation of aldehydes and ketones to synthesize N,N-dimethyl as well as N-methyl tertiary amines, respectively, utilizing ammonium formate and methanol as N1 and C1 sources is reported. The protocol was efficiently extended to a tandem reductive amination/N-methylation/cyclization of keto acids/esters leading to N-methyl lactams. A broad substrate

  Ir(III)配合物催化单还原胺化和双还原胺化，然后利用甲酸铵和甲醇作为N1和C1源，对醛和酮进行N-甲基化，分别合成N、N-二甲基和N-甲基叔胺：报道称。该方案被有效地扩展到酮酸/酯的串联还原胺化/ N-甲基化/环化，产生N-甲基内酰胺。还展示了广泛的底物范围、生物活性分子的合成。进行了控制实验、动力学研究和 DFT 计算，并在此基础上提出了合理的机制。
• Ishii; Mariani, Anales des la Asociacion Quimica Argentina, 1945, vol. 33, p. 167,171
  作者：Ishii、Mariani

  DOI：——

  日期：——